TY - JOUR
T1 - Tissue concentrations of estrogens and aromatase immunolocalization in interstitial pneumonia of human lung
AU - Taniuchi, Shinji
AU - Fujishima, Fumiyoshi
AU - Miki, Yasuhiro
AU - Abe, Keiko
AU - Nakamura, Yasuhiro
AU - Sato, Satoko
AU - Kasajima, Atsuko
AU - Fue, Misaki
AU - Ishida, Kazuyuki
AU - Watanabe, Mika
AU - Sakakibara, Tomohiro
AU - Maeda, Sumiko
AU - Suzuki, Takashi
AU - Sasano, Hironobu
PY - 2014/7/5
Y1 - 2014/7/5
N2 - Interstitial pneumonia (IP) is characterized by various degrees of pulmonary fibrosis and inflammation. Estrogens have been demonstrated to play important roles in physiological and pathological conditions of human lung, but significance of estrogens has remained unknown in human IP. Therefore, we measured estrogen concentrations and immunolocalized aromatase and estrogen receptor β (ERβ) in IP tissues. Estradiol concentration was significantly (2.8-fold) higher in IP than normal lung tissues, and aromatase activity evaluated by estradiol/testosterone ratio was also significantly (7.2-fold) elevated in IP tissues. Aromatase immunoreactivity in alveolar epithelial cells was significantly frequent in IP than normal lung or inflammatory lung disease other than IP, and it was positively associated with ERβ immunoreactivity in these cells of IP. These results suggest that estradiol concentration is locally increased in human IP tissue by aromatase, and increased estrogens may play an important role in the development of IP through ERβ in the alveolar epithelial cells.
AB - Interstitial pneumonia (IP) is characterized by various degrees of pulmonary fibrosis and inflammation. Estrogens have been demonstrated to play important roles in physiological and pathological conditions of human lung, but significance of estrogens has remained unknown in human IP. Therefore, we measured estrogen concentrations and immunolocalized aromatase and estrogen receptor β (ERβ) in IP tissues. Estradiol concentration was significantly (2.8-fold) higher in IP than normal lung tissues, and aromatase activity evaluated by estradiol/testosterone ratio was also significantly (7.2-fold) elevated in IP tissues. Aromatase immunoreactivity in alveolar epithelial cells was significantly frequent in IP than normal lung or inflammatory lung disease other than IP, and it was positively associated with ERβ immunoreactivity in these cells of IP. These results suggest that estradiol concentration is locally increased in human IP tissue by aromatase, and increased estrogens may play an important role in the development of IP through ERβ in the alveolar epithelial cells.
KW - Aromatase
KW - Estrogen
KW - Interstitial pneumonia
KW - Lung
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U2 - 10.1016/j.mce.2014.05.016
DO - 10.1016/j.mce.2014.05.016
M3 - Article
C2 - 24861259
AN - SCOPUS:84901974735
SN - 0303-7207
VL - 392
SP - 136
EP - 143
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 1-2
ER -
