Tongue-like Barrett's esophagus is associated with gastroesophageal reflux disease

Hatsushi Yamagishi, Tomoyuki Koike, Shuichi Ohara, Shigeyuki Kobayashi, Ken Ariizumi, Yasuhiko Abe, Katsunori Iijima, Akira Imatani, Yoshifumi Inomata, Katsuaki Kato, Daisuke Shibuya, Shigemitsu Aida, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Aim: To test this hypothesis of barrett esophagus (BE) classified into two types and to further determine if there was only correlation between the shape of endoscopically suspected esophageal metaplasia (ESEM), prevalence of reflux esophagitis (RE) and heartburn. Methods: A total of 6504 Japanese who underwent endoscopy for their annual stomach check-up were enrolled in this study. BE was detected without histological confirmation that is ESEN. We originally classified cases of ESEM into 3 types based on its shape: Tongue-like (T type), Dome-like (D type) and Wave-like (W type) ESEM. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a one-month period. Results: ESEM was observed in 10.3% of 6504 subjects (ESEM < 1 cm, 9.4%; 1 cm ≤ ESEM < 3 cm, 1.7%; ESEM ≥ 3 cm, 0.5%). The frequency of ESEM was significantly higher in males compared with female subjects. Statistical analysis showed that the prevalence of heartburn and RE were significantly higher in the T type ESEM than in the W type ESEM (P < 0.05). Conclusion: The T type ESEM was strongly associated with reflux symptoms and RE whereas the W type ESEM was not associated with GERD.

Original languageEnglish
Pages (from-to)4196-4203
Number of pages8
JournalWorld Journal of Gastroenterology
Issue number26
Publication statusPublished - 2008


  • Dome-like endoscopically suspected esophageal metaplasia
  • Gastroesophageal reflux disease
  • Tongue-like endoscopically suspected esophageal metaplasia
  • Wage-like endoscopically suspected esophageal metaplasia


Dive into the research topics of 'Tongue-like Barrett's esophagus is associated with gastroesophageal reflux disease'. Together they form a unique fingerprint.

Cite this