Total syntheses of complanadines A and B

Le Zhao, Chihiro Tsukano, Eunsang Kwon, Yoshiji Takemoto, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


Twice as nice: Total syntheses of dimeric alkaloids, (-)-complanadines A (1) and B (2), were achieved from (-)-lycodine. The unsymmetrical motif was assembled through direct arylation of the pyridine N-oxide. The absolute configuration and specific rotations of complanadines A and B were identified. Cbz=Benzyloxycarbonyl.

Original languageEnglish
Pages (from-to)1722-1725
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number6
Publication statusPublished - 2013 Feb 4


  • alkaloids
  • biomimetic synthesis
  • complanadine
  • direct arylation
  • total synthesis


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