Total Syntheses of (+)-Marrubiin and (-)-Marrulibacetal

Hiroyuki Yamakoshi, Yuki Sawayama, Yoshihiro Akahori, Marie Kato, Seiichi Nakamura

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


A stereoselective total synthesis of (+)-marrubiin has been accomplished starting from a chiral building block via the CyNH2-promoted Pauson-Khand reaction (PKR) followed by oxidative cleavage of the resultant cyclopentenone ring. Two successive oxidations and internal transacetalization culminated in the total synthesis of the antispasmodic labdane diterpenoid (-)-marrulibacetal.

Original languageEnglish
Pages (from-to)3430-3433
Number of pages4
JournalOrganic Letters
Issue number14
Publication statusPublished - 2016 Jul 15


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