Total Synthesis and Absolute Stereochemistry of Pentenocin B, a Novel Interleukin-1β Converting Enzyme Inhibitor

Tsutomu Sugahara; Hayato Fukuda; Yoshiharu Iwabuchi

doi:10.1021/jo035430x

Total Synthesis and Absolute Stereochemistry of Pentenocin B, a Novel Interleukin-1β Converting Enzyme Inhibitor

Tsutomu Sugahara, Hayato Fukuda, Yoshiharu Iwabuchi

PHA - Molecular Pharmaceutical Science

Tohoku University

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Four possible diastereomers of pentenocin B were synthesized in a stereocontrolled manner, and the first total synthesis of a natural enantiomer of (+)-pentenocin B unequivocally established the absolute stereochemistry to be 4S,5R,6R.

Original language	English
Pages (from-to)	1744-1747
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	69
Issue number	5
DOIs	https://doi.org/10.1021/jo035430x
Publication status	Published - 2004 Mar 5

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title = "Total Synthesis and Absolute Stereochemistry of Pentenocin B, a Novel Interleukin-1β Converting Enzyme Inhibitor",

abstract = "Four possible diastereomers of pentenocin B were synthesized in a stereocontrolled manner, and the first total synthesis of a natural enantiomer of (+)-pentenocin B unequivocally established the absolute stereochemistry to be 4S,5R,6R.",

author = "Tsutomu Sugahara and Hayato Fukuda and Yoshiharu Iwabuchi",

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AU - Fukuda, Hayato

AU - Iwabuchi, Yoshiharu

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JO - Journal of Organic Chemistry

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Total Synthesis and Absolute Stereochemistry of Pentenocin B, a Novel Interleukin-1β Converting Enzyme Inhibitor

Abstract

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