@article{48723d8e42014bc58fe6bdca32d98b4b,
title = "Total Synthesis and Structural Determination of Cyclodepsipeptide Decatransin",
abstract = "The structure determination of the 30-membered cyclodepsipeptide decatransin was demonstrated on the basis of total synthesis. Both (R)- and (S)-2-hydroxy-5-methylhexanoic acid derivatives were prepared via the Evans asymmetric alkylation. N-Alkyl-enriched peptide fragments were synthesized by the Cbz strategy in the solution phase without formation of diketopiperazine and epimerization. The synthesis of putative candidates was achieved by convergent peptide coupling of three peptide fragments, followed by macrocyclization under the Mitsunobu conditions.",
author = "Kosuke Ohsawa and Sakiko Fukaya and Takayuki Doi",
note = "Funding Information: The authors thank Dr. Dominic Hoepfner and Dr. Philipp Krastel at Novartis Institutes for Biomedical Research for the gift of the precious sample of the natural product (∼0.1 mg). This work was supported by JSPS KAKENHI Grants JP19K16310 (Early-Career Scientists) and 15H05837 (Middle Molecular Strategy). This work was partially supported by the Platform Project for Supporting in Drug Discovery and Life Science Research from AMED under Grant JP22ama121038. The authors thank Prof. Dr. Motoki Takagi at Fukushima Medical University for the evaluation of cytotoxicity and Dr. Masanori Shigeno at Tohoku University for his help in recording CD spectra. Publisher Copyright: {\textcopyright} 2022 American Chemical Society. All rights reserved.",
year = "2022",
month = aug,
day = "5",
doi = "10.1021/acs.orglett.2c02085",
language = "English",
volume = "24",
pages = "5552--5556",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "30",
}