(Chemical Equation Presented) Strong support for the recently proposed structure of the kedarcidin chromophore has been obtained through the convergent synthesis of the aglycon. The key features of the synthesis are an efficient assembly of the four fragments, a novel strategy involving an alkynyl epoxide, a cerium amide promoted nine-membered diyne ring cyclization, and a SmI 2-mediated reductive 1,2-elimination. TBS=tert-butyldimethylsilyl, MOM=methoxymethyl.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2009 Jan 26|
- Antitumor agents
- Total synthesis
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