Total synthesis of apratoxin A

Takayuki Doi, Yoshitaka Numajiri, Asami Munakata, Takashi Takahashi

Research output: Contribution to journalArticlepeer-review

89 Citations (Scopus)


We have achieved a total synthesis of apratoxin A in which thiazoline formation was accomplished from the moCys containing amide 4 using PPh 3(O)/Tf2O. Deprotection of the Troc and allyl ester in 17, coupling with tripeptide 3, and deprotection of the allyl ester and the Fmoc, followed by macrolactamization provided apratoxin A (1).

Original languageEnglish
Pages (from-to)531-534
Number of pages4
JournalOrganic Letters
Issue number3
Publication statusPublished - 2006 Feb 2


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