Total synthesis of avermectin B1a revisited

Shuji Yamashita, Daisuke Hayashi, Aoi Nakano, Yujiro Hayashi, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Avermectins were isolated as compounds possessing anthelmintic activity from the culture broth of Streptomycesavermitilis by O¯mura and co-workers. Owing to their potent anthelmintic and insecticidal activities, as well as their unique pentacyclic architecture, the avermectin family attracted keen interest from synthetic organic chemists. We have recently completed a more efficient and straightforward total synthesis of avermectin B 1a, as compared with previous syntheses.

Original languageEnglish
Pages (from-to)31-50
Number of pages20
JournalJournal of Antibiotics
Issue number1
Publication statusPublished - 2016 Jan 1


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