Total Synthesis of Calicheamicin–Dynemicin Hybrid Molecules

K. C. Nicolaou, Erwin P. Schreiner, Yoshiharu Iwabuchi, Toshio Suzuki

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Synthetic enediyne cytostatics/antibiotics are the goal of the preparative work described here. Of the four isomeric calicheamicin‐dynemicin hybrid compounds obtained, only those with the same configuration as calicheamin at all stereocenters are cytostatically active. One of the active isomers is 1. (Figure Presented.)

Original languageEnglish
Pages (from-to)340-342
Number of pages3
JournalAngewandte Chemie International Edition in English
Issue number3
Publication statusPublished - 1992 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


Dive into the research topics of 'Total Synthesis of Calicheamicin–Dynemicin Hybrid Molecules'. Together they form a unique fingerprint.

Cite this