Total synthesis of (-)-conophylline and (-)-conophyllidine

Yuki Han-Ya; Hidetoshi Tokuyama; Tohru Fukuyama

doi:10.1002/anie.201100981

Total synthesis of (-)-conophylline and (-)-conophyllidine

Yuki Han-Ya, Hidetoshi Tokuyama, Tohru Fukuyama

PHA - Molecular Pharmaceutical Science

The University of Tokyo

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Double take: The total syntheses of the title compounds were accomplished in a highly convergent manner. The approach features the regio- and diastereoselective Polonovski-Potier-type reaction for the coupling of two aspidosperma skeletons and the formation of the dihydrofuran ring. Troc=2,2,2-trichloroethoxycarbonyl.

Original language	English
Pages (from-to)	4884-4887
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	21
DOIs	https://doi.org/10.1002/anie.201100981
Publication status	Published - 2011 May 16

Keywords

alkaloids
cascade reactions
heterocycles
natural products
total synthesis

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10.1002/anie.201100981

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AU - Tokuyama, Hidetoshi

AU - Fukuyama, Tohru

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KW - cascade reactions

KW - heterocycles

KW - natural products

KW - total synthesis

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Total synthesis of (-)-conophylline and (-)-conophyllidine

Abstract

Keywords

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