Total synthesis of (-)-dysiherbaine, a novel neuroexcitotoxic amino acid

Makoto Sasaki, Tatsuki Koike, Ryuichi Sakai, Kazuo Tachibana

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


A total synthesis of (-)-dysiherbaine, a neuroexcitotoxic amino acid isolated from the Micronesian marine sponge Dysidea herbacea, starting from a carbohydrate precursor, is described. The present synthesis features a palladium(0)-catalyzed cross-coupling of the 6/5-bicyclic core with an amino acid residue. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)3923-3926
Number of pages4
JournalTetrahedron Letters
Issue number20
Publication statusPublished - 2000 May 21
Externally publishedYes


  • Amino acids and derivatives
  • Marine metabolites
  • Natural products
  • Toxins

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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