Total synthesis of (-)-dysiherbaine, a novel neuroexcitotoxic amino acid

Makoto Sasaki; Tatsuki Koike; Ryuichi Sakai; Kazuo Tachibana

doi:10.1016/S0040-4039(00)00518-9

Total synthesis of (-)-dysiherbaine, a novel neuroexcitotoxic amino acid

Makoto Sasaki, Tatsuki Koike, Ryuichi Sakai, Kazuo Tachibana

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A total synthesis of (-)-dysiherbaine, a neuroexcitotoxic amino acid isolated from the Micronesian marine sponge Dysidea herbacea, starting from a carbohydrate precursor, is described. The present synthesis features a palladium(0)-catalyzed cross-coupling of the 6/5-bicyclic core with an amino acid residue. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	3923-3926
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	20
DOIs	https://doi.org/10.1016/S0040-4039(00)00518-9
Publication status	Published - 2000 May 21
Externally published	Yes

Keywords

Amino acids and derivatives
Marine metabolites
Natural products
Toxins

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0040-4039(00)00518-9

Cite this

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title = "Total synthesis of (-)-dysiherbaine, a novel neuroexcitotoxic amino acid",

abstract = "A total synthesis of (-)-dysiherbaine, a neuroexcitotoxic amino acid isolated from the Micronesian marine sponge Dysidea herbacea, starting from a carbohydrate precursor, is described. The present synthesis features a palladium(0)-catalyzed cross-coupling of the 6/5-bicyclic core with an amino acid residue. (C) 2000 Elsevier Science Ltd.",

keywords = "Amino acids and derivatives, Marine metabolites, Natural products, Toxins",

author = "Makoto Sasaki and Tatsuki Koike and Ryuichi Sakai and Kazuo Tachibana",

note = "Funding Information: This work was financially supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, of Japan.",

year = "2000",

month = may,

day = "21",

doi = "10.1016/S0040-4039(00)00518-9",

language = "English",

volume = "41",

pages = "3923--3926",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

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TY - JOUR

T1 - Total synthesis of (-)-dysiherbaine, a novel neuroexcitotoxic amino acid

AU - Sasaki, Makoto

AU - Koike, Tatsuki

AU - Sakai, Ryuichi

AU - Tachibana, Kazuo

N1 - Funding Information: This work was financially supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, of Japan.

PY - 2000/5/21

Y1 - 2000/5/21

N2 - A total synthesis of (-)-dysiherbaine, a neuroexcitotoxic amino acid isolated from the Micronesian marine sponge Dysidea herbacea, starting from a carbohydrate precursor, is described. The present synthesis features a palladium(0)-catalyzed cross-coupling of the 6/5-bicyclic core with an amino acid residue. (C) 2000 Elsevier Science Ltd.

AB - A total synthesis of (-)-dysiherbaine, a neuroexcitotoxic amino acid isolated from the Micronesian marine sponge Dysidea herbacea, starting from a carbohydrate precursor, is described. The present synthesis features a palladium(0)-catalyzed cross-coupling of the 6/5-bicyclic core with an amino acid residue. (C) 2000 Elsevier Science Ltd.

KW - Amino acids and derivatives

KW - Marine metabolites

KW - Natural products

KW - Toxins

UR - http://www.scopus.com/inward/record.url?scp=0034697479&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034697479&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)00518-9

DO - 10.1016/S0040-4039(00)00518-9

M3 - Article

AN - SCOPUS:0034697479

SN - 0040-4039

VL - 41

SP - 3923

EP - 3926

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 20

ER -

Total synthesis of (-)-dysiherbaine, a novel neuroexcitotoxic amino acid

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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