Total synthesis of gambierol

Haruhiko Fuwa, Makoto Sasaki, Masayuki Satake, Kazuo Tachibana

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)


(Formula Represented) The first total synthesis of gambierol, a marine polycyclic ether toxin, has been achieved. The synthesis features the Pd(PPh3)4/CuCl/LiCl-promoted Stille coupling for the stereoselective construction of the sensitive triene side chain that includes a conjugated (Z,Z)-diene moiety. † The University of Tokyo and CREST, JST. ‡ Tohoku University.

Original languageEnglish
Pages (from-to)2981-2984
Number of pages4
JournalOrganic Letters
Issue number17
Publication statusPublished - 2002 Aug 22


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