Total synthesis of gambierol

Haruhiko Fuwa; Makoto Sasaki; Masayuki Satake; Kazuo Tachibana

doi:10.1021/ol026394b

Total synthesis of gambierol

Haruhiko Fuwa, Makoto Sasaki, Masayuki Satake, Kazuo Tachibana

LIF - Molecular and Chemical Life Science

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

(Formula Represented) The first total synthesis of gambierol, a marine polycyclic ether toxin, has been achieved. The synthesis features the Pd(PPh₃)₄/CuCl/LiCl-promoted Stille coupling for the stereoselective construction of the sensitive triene side chain that includes a conjugated (Z,Z)-diene moiety. † The University of Tokyo and CREST, JST. ‡ Tohoku University.

Original language	English
Pages (from-to)	2981-2984
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	17
DOIs	https://doi.org/10.1021/ol026394b
Publication status	Published - 2002 Aug 22

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10.1021/ol026394b

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abstract = "(Formula Represented) The first total synthesis of gambierol, a marine polycyclic ether toxin, has been achieved. The synthesis features the Pd(PPh3)4/CuCl/LiCl-promoted Stille coupling for the stereoselective construction of the sensitive triene side chain that includes a conjugated (Z,Z)-diene moiety. † The University of Tokyo and CREST, JST. ‡ Tohoku University.",

author = "Haruhiko Fuwa and Makoto Sasaki and Masayuki Satake and Kazuo Tachibana",

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Total synthesis of gambierol

Abstract

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