Total synthesis of (-)-polycavernoside A: Suzuki-Miyaura coupling approach

Yusuke Kasai; Takanori Ito; Makoto Sasaki

doi:10.1021/ol301278e

Total synthesis of (-)-polycavernoside A: Suzuki-Miyaura coupling approach

Yusuke Kasai, Takanori Ito, Makoto Sasaki

LIF - Molecular and Chemical Life Science

Tohoku University

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A total synthesis of (-)-polycavernoside A, a marine lethal toxin isolated from the edible alga Gracilaria edulis, has been achieved via a convergent approach. The synthesis is highlighted by catalytic asymmetric syntheses of the two key fragments and their union through Suzuki-Miyaura coupling and Keck macrolactonization.

Original language	English
Pages (from-to)	3186-3189
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	12
DOIs	https://doi.org/10.1021/ol301278e
Publication status	Published - 2012 Jun 15

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/ol301278e

Cite this

@article{526571b26cf047d082ac365400e42663,

title = "Total synthesis of (-)-polycavernoside A: Suzuki-Miyaura coupling approach",

abstract = "A total synthesis of (-)-polycavernoside A, a marine lethal toxin isolated from the edible alga Gracilaria edulis, has been achieved via a convergent approach. The synthesis is highlighted by catalytic asymmetric syntheses of the two key fragments and their union through Suzuki-Miyaura coupling and Keck macrolactonization.",

author = "Yusuke Kasai and Takanori Ito and Makoto Sasaki",

year = "2012",

month = jun,

day = "15",

doi = "10.1021/ol301278e",

language = "English",

volume = "14",

pages = "3186--3189",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - Total synthesis of (-)-polycavernoside A

T2 - Suzuki-Miyaura coupling approach

AU - Kasai, Yusuke

AU - Ito, Takanori

AU - Sasaki, Makoto

PY - 2012/6/15

Y1 - 2012/6/15

N2 - A total synthesis of (-)-polycavernoside A, a marine lethal toxin isolated from the edible alga Gracilaria edulis, has been achieved via a convergent approach. The synthesis is highlighted by catalytic asymmetric syntheses of the two key fragments and their union through Suzuki-Miyaura coupling and Keck macrolactonization.

AB - A total synthesis of (-)-polycavernoside A, a marine lethal toxin isolated from the edible alga Gracilaria edulis, has been achieved via a convergent approach. The synthesis is highlighted by catalytic asymmetric syntheses of the two key fragments and their union through Suzuki-Miyaura coupling and Keck macrolactonization.

UR - http://www.scopus.com/inward/record.url?scp=84862513587&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862513587&partnerID=8YFLogxK

U2 - 10.1021/ol301278e

DO - 10.1021/ol301278e

M3 - Article

C2 - 22671133

AN - SCOPUS:84862513587

SN - 1523-7060

VL - 14

SP - 3186

EP - 3189

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Total synthesis of (-)-polycavernoside A: Suzuki-Miyaura coupling approach

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this