Total synthesis of the duocarmycins

Ken Yamada, Toshiki Kurokawa, Hidetoshi Tokuyama, Tohru Fukuyama

Research output: Contribution to journalArticlepeer-review

121 Citations (Scopus)


The total synthesis of (+)-duocarmycin A and SA through a common indoline intermediate is described. The key reactions include selective lithiation of a 2,6-dibromoiodobenzene derivative and diastereoselective addition to a chiral nitroalkene, copper-mediated aryl amination, and addition of aryllithium to azlactones.

Original languageEnglish
Pages (from-to)6630-6631
Number of pages2
JournalJournal of the American Chemical Society
Issue number22
Publication statusPublished - 2003 Jun 4
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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