The total synthesis of (+)-duocarmycin A and SA through a common indoline intermediate is described. The key reactions include selective lithiation of a 2,6-dibromoiodobenzene derivative and diastereoselective addition to a chiral nitroalkene, copper-mediated aryl amination, and addition of aryllithium to azlactones.
|Number of pages||2|
|Journal||Journal of the American Chemical Society|
|Publication status||Published - 2003 Jun 4|
ASJC Scopus subject areas
- Colloid and Surface Chemistry