@article{ed40eeecad584fd7aa32383a9948bdb2,
title = "Toward a total synthesis of amphidinolide N: convergent synthesis of the C1–C13 segment",
abstract = "A convergent synthesis of the C1–C13 segment of amphidinolide N, a potent cytotoxic marine macrolide isolated from the dinoflagellate Amphidinium sp., was achieved. The key features of the synthesis involve vinylogous Mukaiyama and Evans aldol reactions to form the C1–C7 and C8–C13 fragments, and convergent union of the two fragments by means of an aldol reaction to construct the C1–C13 segment.",
keywords = "Aldol reaction, Amphidinolide N, Convergent synthesis, Cytotoxic macrolide",
author = "Atsushi Toyoshima and Makoto Sasaki",
note = "Funding Information: We thank Professor Haruhiko Fuwa (Tohoku University) for helpful discussions. This work was financially supported in part by a Grant-in-Aid for Scientific Research (B) (No. 25282228 ) and Scientific Research on Innovative Areas {\textquoteleft}Chemical Biology of Natural Products{\textquoteright} (No. 23102016 ) 24 from the Japan Society for the Promotion of Science ( JSPS ). Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",
year = "2016",
doi = "10.1016/j.tetlet.2016.06.107",
language = "English",
volume = "57",
pages = "3532--3534",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "31",
}
