TY - JOUR
T1 - Tracheobronchial mucociliary clearance and alveolar epithelial permeability measured by PET with18FDG powder
AU - Hatazawa, Jun
AU - Yanai, Masaru
AU - Itoh, Masatoshi
AU - Ido, Tatsuo
AU - Ojima, Fumiyoshi
AU - Takahashi, Toshihiro
AU - Aikawa, T.
AU - Sasaki, Hidetada
AU - Takishima, Tamotsu
AU - Watanuki, Shoichi
AU - Seo, Shinya
AU - Abiko, Kenji
AU - Amano, Masafumi
PY - 1990/3
Y1 - 1990/3
N2 - Tracheobronchial mucociliary clearance and alveolar permeability were measured with positron emission tomography using a water-soluble dry aerosol, sodium-N-acetyl-neuraminate tagged with 2-deoxy-2-[18F]fluoro-D- glucose (18FDG powder). Five normal volunteers inhaled 1.5-2.0 mCi of FDG powder by a single deep breath. The distribution of radioactivity, measured by scanning during a period of 120 min, showed that the 18FDG powder deposition progressed from the central airways to the peripheral alveolar areas. In the tracheobronchial system the radioactivity decreased to 24% of the initial deposition at 60 min. In the peripheral alveolar area, where absorption into blood or lymphatic flow crossing the epithelial layer represents a unique mechanism of clearance for water-soluble 18FDG powder, alveolar radioactivity decreased slowly to~70% of the initial deposition at 60 min after inhalation. Positron emission tomography using18FDG powder provides a regional evaluation of both mucociliary transport in the tracheobronchial system and epithelial permeability in the alveolar area.
AB - Tracheobronchial mucociliary clearance and alveolar permeability were measured with positron emission tomography using a water-soluble dry aerosol, sodium-N-acetyl-neuraminate tagged with 2-deoxy-2-[18F]fluoro-D- glucose (18FDG powder). Five normal volunteers inhaled 1.5-2.0 mCi of FDG powder by a single deep breath. The distribution of radioactivity, measured by scanning during a period of 120 min, showed that the 18FDG powder deposition progressed from the central airways to the peripheral alveolar areas. In the tracheobronchial system the radioactivity decreased to 24% of the initial deposition at 60 min. In the peripheral alveolar area, where absorption into blood or lymphatic flow crossing the epithelial layer represents a unique mechanism of clearance for water-soluble 18FDG powder, alveolar radioactivity decreased slowly to~70% of the initial deposition at 60 min after inhalation. Positron emission tomography using18FDG powder provides a regional evaluation of both mucociliary transport in the tracheobronchial system and epithelial permeability in the alveolar area.
KW - Contrast media, Inhalation agents
KW - Emission Computed tomography
KW - Lungs
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U2 - 10.1097/00004728-199003000-00003
DO - 10.1097/00004728-199003000-00003
M3 - Article
C2 - 2312843
AN - SCOPUS:0025215806
SN - 0363-8715
VL - 14
SP - 175
EP - 181
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
IS - 2
ER -