Traditional Chinese medicine on four patients with Huntington's disease

Takashi Satoh, Toshiyuki Takahashi, Koh Iwasaki, Hideaki Tago, Takashi Seki, Nobuo Yaegashi, Muneshige Tobita, Hiroyuki Arai

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Four Huntington's disease (HD) patients were treated with traditional Chinese medicines Yi-Gan San (YGS) and Chaihu-Jia-Longgu-Muli Tan (CLMT) in a cross-over manner. Two patients took YGS for 8 weeks first, and after 4 weeks of washing out, they took CLMT for 8 weeks. Two other patients took these medicines in reverse order. All patients showed a decrease in the Unified Huntington's Disease Rating Scale - motor assessment (from 106.3 ± 4.7 to 89.6 ± 5.8 as mean ± SD, P = 0.0004) by YGS treatment with no extrapiramidal symptoms or changes of cognition or ADL. Our study suggests a possibility of a new treatment for involuntary movements.

Original languageEnglish
Pages (from-to)453-455
Number of pages3
JournalMovement Disorders
Issue number3
Publication statusPublished - 2009 Feb 15


  • Chorea
  • Huntington's disease
  • Movement disorder
  • Traditional Chinese medicine
  • Yi-Gan San (yokukansan)

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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