Traditional Chinese medicine on four patients with Huntington's disease

Takashi Satoh; Toshiyuki Takahashi; Koh Iwasaki; Hideaki Tago; Takashi Seki; Nobuo Yaegashi; Muneshige Tobita; Hiroyuki Arai

doi:10.1002/mds.22447

Traditional Chinese medicine on four patients with Huntington's disease

Takashi Satoh, Toshiyuki Takahashi, Koh Iwasaki, Hideaki Tago, Takashi Seki, Nobuo Yaegashi, Muneshige Tobita, Hiroyuki Arai

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Four Huntington's disease (HD) patients were treated with traditional Chinese medicines Yi-Gan San (YGS) and Chaihu-Jia-Longgu-Muli Tan (CLMT) in a cross-over manner. Two patients took YGS for 8 weeks first, and after 4 weeks of washing out, they took CLMT for 8 weeks. Two other patients took these medicines in reverse order. All patients showed a decrease in the Unified Huntington's Disease Rating Scale - motor assessment (from 106.3 ± 4.7 to 89.6 ± 5.8 as mean ± SD, P = 0.0004) by YGS treatment with no extrapiramidal symptoms or changes of cognition or ADL. Our study suggests a possibility of a new treatment for involuntary movements.

Original language	English
Pages (from-to)	453-455
Number of pages	3
Journal	Movement Disorders
Volume	24
Issue number	3
DOIs	https://doi.org/10.1002/mds.22447
Publication status	Published - 2009 Feb 15

Keywords

Chorea
Huntington's disease
Movement disorder
Traditional Chinese medicine
Yi-Gan San (yokukansan)

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.22447

Cite this

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abstract = "Four Huntington's disease (HD) patients were treated with traditional Chinese medicines Yi-Gan San (YGS) and Chaihu-Jia-Longgu-Muli Tan (CLMT) in a cross-over manner. Two patients took YGS for 8 weeks first, and after 4 weeks of washing out, they took CLMT for 8 weeks. Two other patients took these medicines in reverse order. All patients showed a decrease in the Unified Huntington's Disease Rating Scale - motor assessment (from 106.3 ± 4.7 to 89.6 ± 5.8 as mean ± SD, P = 0.0004) by YGS treatment with no extrapiramidal symptoms or changes of cognition or ADL. Our study suggests a possibility of a new treatment for involuntary movements.",

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AU - Satoh, Takashi

AU - Takahashi, Toshiyuki

AU - Iwasaki, Koh

AU - Tago, Hideaki

AU - Seki, Takashi

AU - Yaegashi, Nobuo

AU - Tobita, Muneshige

AU - Arai, Hiroyuki

PY - 2009/2/15

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Traditional Chinese medicine on four patients with Huntington's disease

Abstract

Keywords

ASJC Scopus subject areas

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