Transamidation of amides with amines under solvent-free conditions using a CeO2 catalyst

Masazumi Tamura, Takuya Tonomura, Ken Ichi Shimizu, Atsushi Satsuma

Research output: Contribution to journalArticlepeer-review

137 Citations (Scopus)


Among various metal oxides, cerium oxide (CeO2) shows the highest catalytic activity for transamidation of picolinamide with n-octylamine. CeO2 acts as a reusable and effective heterogeneous catalyst for transamidation under solvent-free conditions. Transamidation of a variety of amides and amines produced the corresponding N-alkyl amides in high yields. This method provides the first example of a heterogeneous catalyst for transamidation using aliphatic amines as substrates. Characterization of acid–base properties and kinetic studies suggest that the cooperation of the weak Lewis acid sites and adjacent strong base sites play important roles in the transamidation reaction.

Original languageEnglish
Pages (from-to)717-724
Number of pages8
JournalGreen Chemistry
Issue number3
Publication statusPublished - 2012 Jan 3
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution


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