Abstract
Transcriptional activity of nuclei from human diploid fibroblast (WI‐38) cells at different passage levels was studied with endogenous RNA polymerase. The rate and extent of the RNA synthesis decreased when the nuclei were were prepared from senescent cells. The decreased activity of RNA synthesis in senescent cell nuclei was demonstrated from both the transcriptional assay and the estimation of the processing activity, i.e., polyadenylation of the transcripts.
| Original language | English |
|---|---|
| Pages (from-to) | 51-54 |
| Number of pages | 4 |
| Journal | Journal of Cellular Physiology |
| Volume | 102 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1980 Jan |