Transesophageal endoscopic ultrasonography guided-fine needle aspiration for the diagnosis of sarcoidosis

Kazue Saito; Yoshinori Tanino; Yayoi Inokoshi; Suguru Sato; Kengo Oshima; Taeko Ishii; Naoko Nakagawa; Atsuro Fukuhar; Kenya Kanazawa; Junpei Saito; Takashi Ishida; Takuto Hikichi; Atsushi Irisawa; Hiromasa Ohira; Mitsuru Munakata

Transesophageal endoscopic ultrasonography guided-fine needle aspiration for the diagnosis of sarcoidosis

Kazue Saito, Yoshinori Tanino, Yayoi Inokoshi, Suguru Sato, Kengo Oshima, Taeko Ishii, Naoko Nakagawa, Atsuro Fukuhar, Kenya Kanazawa, Junpei Saito, Takashi Ishida, Takuto Hikichi, Atsushi Irisawa, Hiromasa Ohira, Mitsuru Munakata

HOSP - Internal Medicine

Fukushima Medical University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Sarcoidosis is a multi-organ disorder of unknown etiology characterized by noncaseating epithelioid cell granulomas. The specimen for histopathological diagnosis is usually obtained by transbronchial lung biopsy (TBLB), but the diagnostic accuracy rate of TBLB is not satisfactory, especially for stage I patients. Since hilar and mediastinal lymphadenopathy is a common finding in patients with sarcoidosis, an approach to lymph nodes is expected to have a good diagnosis yield. We present 3 sarcoidosis patients in whom specimens obtained by TBLB, transbronchial needle aspiration (TBNA) and transesophageal endoscopic ultrasonography guided-fine needle aspiration (EUS-FNA). The histopathological appearance of specimens obtained by EUS-FNA for swollen mediastinal lymph nodes showed noncaseating epithelioid granulomas which are characteristic of sarcoidosis in all 3 patients. On the other hand, no specific findings were recognized in the specimens obtained by TBLB and TBNA in 2 out of 3 patients. These results suggest that EUS-FNA is useful to obtain diagnostic specimens in cases of sarcoidosis.

Original language	English
Pages (from-to)	996-1001
Number of pages	6
Journal	Respiratory Investigation
Volume	47
Issue number	11
Publication status	Published - 2009 Nov

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title = "Transesophageal endoscopic ultrasonography guided-fine needle aspiration for the diagnosis of sarcoidosis",

abstract = "Sarcoidosis is a multi-organ disorder of unknown etiology characterized by noncaseating epithelioid cell granulomas. The specimen for histopathological diagnosis is usually obtained by transbronchial lung biopsy (TBLB), but the diagnostic accuracy rate of TBLB is not satisfactory, especially for stage I patients. Since hilar and mediastinal lymphadenopathy is a common finding in patients with sarcoidosis, an approach to lymph nodes is expected to have a good diagnosis yield. We present 3 sarcoidosis patients in whom specimens obtained by TBLB, transbronchial needle aspiration (TBNA) and transesophageal endoscopic ultrasonography guided-fine needle aspiration (EUS-FNA). The histopathological appearance of specimens obtained by EUS-FNA for swollen mediastinal lymph nodes showed noncaseating epithelioid granulomas which are characteristic of sarcoidosis in all 3 patients. On the other hand, no specific findings were recognized in the specimens obtained by TBLB and TBNA in 2 out of 3 patients. These results suggest that EUS-FNA is useful to obtain diagnostic specimens in cases of sarcoidosis.",

author = "Kazue Saito and Yoshinori Tanino and Yayoi Inokoshi and Suguru Sato and Kengo Oshima and Taeko Ishii and Naoko Nakagawa and Atsuro Fukuhar and Kenya Kanazawa and Junpei Saito and Takashi Ishida and Takuto Hikichi and Atsushi Irisawa and Hiromasa Ohira and Mitsuru Munakata",

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T1 - Transesophageal endoscopic ultrasonography guided-fine needle aspiration for the diagnosis of sarcoidosis

AU - Saito, Kazue

AU - Tanino, Yoshinori

AU - Inokoshi, Yayoi

AU - Sato, Suguru

AU - Oshima, Kengo

AU - Ishii, Taeko

AU - Nakagawa, Naoko

AU - Fukuhar, Atsuro

AU - Kanazawa, Kenya

AU - Saito, Junpei

AU - Ishida, Takashi

AU - Hikichi, Takuto

AU - Irisawa, Atsushi

AU - Ohira, Hiromasa

AU - Munakata, Mitsuru

PY - 2009/11

Y1 - 2009/11

N2 - Sarcoidosis is a multi-organ disorder of unknown etiology characterized by noncaseating epithelioid cell granulomas. The specimen for histopathological diagnosis is usually obtained by transbronchial lung biopsy (TBLB), but the diagnostic accuracy rate of TBLB is not satisfactory, especially for stage I patients. Since hilar and mediastinal lymphadenopathy is a common finding in patients with sarcoidosis, an approach to lymph nodes is expected to have a good diagnosis yield. We present 3 sarcoidosis patients in whom specimens obtained by TBLB, transbronchial needle aspiration (TBNA) and transesophageal endoscopic ultrasonography guided-fine needle aspiration (EUS-FNA). The histopathological appearance of specimens obtained by EUS-FNA for swollen mediastinal lymph nodes showed noncaseating epithelioid granulomas which are characteristic of sarcoidosis in all 3 patients. On the other hand, no specific findings were recognized in the specimens obtained by TBLB and TBNA in 2 out of 3 patients. These results suggest that EUS-FNA is useful to obtain diagnostic specimens in cases of sarcoidosis.

AB - Sarcoidosis is a multi-organ disorder of unknown etiology characterized by noncaseating epithelioid cell granulomas. The specimen for histopathological diagnosis is usually obtained by transbronchial lung biopsy (TBLB), but the diagnostic accuracy rate of TBLB is not satisfactory, especially for stage I patients. Since hilar and mediastinal lymphadenopathy is a common finding in patients with sarcoidosis, an approach to lymph nodes is expected to have a good diagnosis yield. We present 3 sarcoidosis patients in whom specimens obtained by TBLB, transbronchial needle aspiration (TBNA) and transesophageal endoscopic ultrasonography guided-fine needle aspiration (EUS-FNA). The histopathological appearance of specimens obtained by EUS-FNA for swollen mediastinal lymph nodes showed noncaseating epithelioid granulomas which are characteristic of sarcoidosis in all 3 patients. On the other hand, no specific findings were recognized in the specimens obtained by TBLB and TBNA in 2 out of 3 patients. These results suggest that EUS-FNA is useful to obtain diagnostic specimens in cases of sarcoidosis.

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C2 - 19994594

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JO - Respiratory Investigation

JF - Respiratory Investigation

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Transesophageal endoscopic ultrasonography guided-fine needle aspiration for the diagnosis of sarcoidosis

Abstract

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