Transgenerational epigenetic information through the sperm: Sperm cells not just merely supply half of the genome for new life; they also seem to transmit additional information via epigenetic modifications

TY - JOUR

T1 - Transgenerational epigenetic information through the sperm

T2 - Sperm cells not just merely supply half of the genome for new life; they also seem to transmit additional information via epigenetic modifications

AU - Osumi, Noriko

AU - Tatehana, Misako

N1 - Funding Information: The authors acknowledge the financial support of MEXT (16H06530, 15K12764). M.T. is supported by Research Fellowship for Young Scientists of Japan Society for the Promotion of Science. Prevalence of ASD Baio J et al (2018) Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2014. MMWR Surveill Summ 67: 1–23 Weintraub K (2011) The prevalence puzzle: Autism counts. Nature 479: 22–24 Ageing oocytes Keefe D, Kumar M, Kalmbach K (2015) Oocyte competency is the key to embryo potential. Fertil Steril 103: 317–322 Ma JY, Li S, Chen LN, Schatten H, Ou XH, Sun QY (2020) Why is oocyte aneuploidy increased with maternal aging? J Genet Genomics 47: 659–671 Transgenerational epigenetic inheritance Bošković A, Rando OJ (2018) Transgenerational Epigenetic Inheritance. Annu Rev Genet 52: 21–41 Jenkins TG, James ER, Alonso DF, Hoidal JR, Murphy PJ, Hotaling JM, Cairns BR, Carrell DT, Aston KI (2017) Cigarette smoking significantly alters sperm DNA methylation patterns. Andrology 5: 1089–1099 Manikkam M, Tracey R, Guerrero-Bosagna C, Skinner MK (2013) Plastics derived endocrine disruptors (BPA, DEHP and DBP) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations. PLoS One 8: e55387 McPherson NO, Owens JA, Fullston T, Lane M (2015) Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring. Am J Physiol Endocrinol Metab 308: E805–821 Santi D, De Vincentis S, Magnani E, Spaggiari G (2017) Impairment of sperm DNA methylation in male infertility: a meta-analytic study. Andrology 5: 695–703 Histone modifications Burgers WA, Fuks F, Kouzarides T (2002) DNA methyltransferases get connected to chromatin. Trends Genet 18: 275–277 Tatehana M, Kimura R, Mochizuki K, Inada H, Osumi N (2020) Comprehensive histochemical profiles of histone modification in male germline cells during meiosis and spermiogenesis: Comparison of young and aged testes in mice. PLoS One 15: e0230930 Taylor JL, Debost JPG, Morton SU, Wigdor EM, Heyne HO, Lal D, Howrigan DP, Bloemendal A, Larsen JT, Kosmicki JA et al (2019) Paternal-age-related de novo mutations and risk for five disorders. Nat Commun 10: 3043 Funding Information: The authors acknowledge the financial support of MEXT (16H06530, 15K12764). M.T. is supported by Research Fellowship for Young Scientists of Japan Society for the Promotion of Science.

PY - 2021/8/4

Y1 - 2021/8/4

UR - http://www.scopus.com/inward/record.url?scp=85110800951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85110800951&partnerID=8YFLogxK

U2 - 10.15252/embr.202153539

DO - 10.15252/embr.202153539

M3 - Comment/debate

C2 - 34288347

AN - SCOPUS:85110800951

SN - 1469-221X

VL - 22

JO - EMBO Reports

JF - EMBO Reports

IS - 8

M1 - e53539

ER -