Transgenic rice expressing amyloid β-peptide for oral immunization

Taiji Yoshida, Eiichi Kimura, Setsuo Koike, Jun Nojima, Eugene Futai, Noboru Sasagawa, Yuichiro Watanabe, Shoichi Ishiura

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Various vaccine therapies for Alzheimer's disease (AD) have been investigated. Here we report transgenic rice expressing amyloid β-peptide (Aβ). The Aβ42 gene fused with a green fluorescent protein gene was introduced into rice using the Agrobacterium method. When transgenic brown rice expressing Aβ was orally administered to mice, serum anti-Aβ antibody titers were elevated. The same results were observed when mice were fed boiled, transgenic brown rice. The results indicate that an edible vaccine against AD using rice may be feasible. A vaccine derived from rice would be far cheaper than existing medical vaccines.

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalInternational Journal of Biological Sciences
Issue number3
Publication statusPublished - 2011


  • Alzheimer's disease
  • Amyloid β-peptide
  • Brown rice
  • Edible vaccine
  • Oryza sativa


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