Transient global cerebral ischemia model in mice

Kuniyasu Niizuma, Hidenori Endo, Chikako Nito, D. Jeannie Myer, Gab Seok Kim, Teiji Tominaga, Pak H. Chan

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


The transient global ischemia model is used to analyze selective neuronal death in vulnerable regions including the CA1 subregion of the hippocampus and in certain cortical neurons. In this mouse global ischemia model, bilateral common carotid arteries are reversibly occluded, and the individual anatomical backgrounds are normalized by evaluating the patency of the posterior communicating artery. Using this evaluation, this model might be used for mouse strains with various genetic backgrounds.

Original languageEnglish
Title of host publicationAnimal Models of Acute Neurological Injuries
PublisherHumana Press
Number of pages11
ISBN (Print)9781603271844
Publication statusPublished - 2009


  • Blood flow
  • Delayed neuronal death
  • Global cerebral ischemia model
  • Hippocampus
  • Ischemic brain injury
  • Mice

ASJC Scopus subject areas

  • Neuroscience(all)
  • Agricultural and Biological Sciences(all)


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