Transient global cerebral ischemia model in mice

Kuniyasu Niizuma; Hidenori Endo; Chikako Nito; D. Jeannie Myer; Gab Seok Kim; Teiji Tominaga; Pak H. Chan

doi:10.1007/978-1-60327-185-1_10

Transient global cerebral ischemia model in mice

Kuniyasu Niizuma, Hidenori Endo, Chikako Nito, D. Jeannie Myer, Gab Seok Kim, Teiji Tominaga, Pak H. Chan

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

The transient global ischemia model is used to analyze selective neuronal death in vulnerable regions including the CA1 subregion of the hippocampus and in certain cortical neurons. In this mouse global ischemia model, bilateral common carotid arteries are reversibly occluded, and the individual anatomical backgrounds are normalized by evaluating the patency of the posterior communicating artery. Using this evaluation, this model might be used for mouse strains with various genetic backgrounds.

Original language	English
Title of host publication	Animal Models of Acute Neurological Injuries
Publisher	Humana Press
Pages	115-125
Number of pages	11
ISBN (Print)	9781603271844
DOIs	https://doi.org/10.1007/978-1-60327-185-1_10
Publication status	Published - 2009

Keywords

Blood flow
Delayed neuronal death
Global cerebral ischemia model
Hippocampus
Ischemic brain injury
Mice

ASJC Scopus subject areas

Neuroscience(all)
Agricultural and Biological Sciences(all)

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10.1007/978-1-60327-185-1_10

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keywords = "Blood flow, Delayed neuronal death, Global cerebral ischemia model, Hippocampus, Ischemic brain injury, Mice",

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AU - Niizuma, Kuniyasu

AU - Endo, Hidenori

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AU - Myer, D. Jeannie

AU - Kim, Gab Seok

AU - Tominaga, Teiji

AU - Chan, Pak H.

PY - 2009

Y1 - 2009

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AB - The transient global ischemia model is used to analyze selective neuronal death in vulnerable regions including the CA1 subregion of the hippocampus and in certain cortical neurons. In this mouse global ischemia model, bilateral common carotid arteries are reversibly occluded, and the individual anatomical backgrounds are normalized by evaluating the patency of the posterior communicating artery. Using this evaluation, this model might be used for mouse strains with various genetic backgrounds.

KW - Blood flow

KW - Delayed neuronal death

KW - Global cerebral ischemia model

KW - Hippocampus

KW - Ischemic brain injury

KW - Mice

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BT - Animal Models of Acute Neurological Injuries

PB - Humana Press

ER -

Transient global cerebral ischemia model in mice

Abstract

Keywords

ASJC Scopus subject areas

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