Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I

Makoto Kanzaki, You Qing Zhang, Hirosato Mashima, Lu Li, Hiroshi Shibata, Itaru Kojima

Research output: Contribution to journalArticlepeer-review

419 Citations (Scopus)


Calcium plays a critical part in the regulation of cell growth, and growth factors stimulate calcium entry into cells through calcium-permeable channels. However, the molecular nature and regulation of calcium-permeable channels are still unclear at present. Here we report the molecular characterization of a calcium-permeable cation channel that is regulated by insulin-like growth factor-I (IGF-I). This channel, which we name growth-factor-regulated channel (GRC), belongs to the TRP-channel family and localizes mainly to intracellular pools under basal conditions. Upon stimulation of cells by IGF-I, GRC translocates to the plasma membrane. Thus, IGF-I augments calcium entry through GRC by regulating trafficking of the channel.

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalNature Cell Biology
Issue number3
Publication statusPublished - 1999 Jul


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