Abstract
Current strategy for the treatment of periodontal disease is to application of stem cells or functional molecules that can reorganize tissue integrity, cellular activities and extracellular matrix framework to recover peridontal tissue function. The approach to be regeneration of periodontal ligament (PDL) that is a tooth supporting connective tissue has made a progress for consideration of strategies in regeneration therapy of periodontal tissue damaged by periodontitis. To realize the achieving functional PDL regeneration, the application of stem cells and functional molecules which are essential for PDL regeneration/development must be developed. The identification of stem cells/progenitors and functional molecules that contribute PDL regeneration will substantial contribution for realization of the regeneration therapy as a novel treatment of connective tissue disease. This review describes current strategy of functional PDL regeneration based on development, stem cell biology and tissue engineering after pathological degradation by periodontitis. The present status of the hurdles to this technology are also described and discussed.
| Original language | English |
|---|---|
| Title of host publication | Interface Oral Health Science 2014 |
| Subtitle of host publication | Innovative Research on Biosis-Abiosis Intelligent Interface |
| Publisher | Springer Japan |
| Pages | 169-180 |
| Number of pages | 12 |
| ISBN (Electronic) | 9784431551928 |
| ISBN (Print) | 9784431551256 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
Keywords
- Extracellular matrix
- Marfan syndrome
- Microfibril
- Periodontal ligament
- Regeneration therapy