@article{ce701b1f9b3d49c08f27ec4867c77cc5,
title = "Tropone skeleton enhances the dispersion stability of nano-prodrugs",
abstract = "We synthesized hinokitiol-modified SN-38 prodrugs and fabricated their nano-prodrugs which are nanoparticles composed of only prodrug molecules by the reprecipitation method. These nano-prodrugs possessed high dispersion stability, and further research revealed that the tropone skeleton of hinokitiol is the key structure for the dispersion stability in our prodrug design. In addition, the nanoparticles of hinokitiol-modified SN-38 showed much higher cytotoxicity against cancer cells than irinotecan, the pharmaceutically available prodrug of SN-38.",
keywords = "Drug delivery system, Reprecipitation method, Tropone skeleton",
author = "Keita Tanita and Yoshitaka Koseki and Takaaki Kamishima and Hitoshi Kasai",
note = "Funding Information: We would like to thank Dr. Hiroshi Yabu of IMRAM, Tohoku University, who established the in vitro experiment. This study was supported by JSPS Grants-in-Aid for Scientific Research (No. 19K15690, and No. 19H02785), the Cooperative Research Program of “Network Joint Research Center for Materials and Devices”, and the Research Program of “Dynamic Alliance for Open Innovation Bridging Human, Environment and Materials” in “Network Joint Research Center for Materials and Devices”. Publisher Copyright: {\textcopyright} 2020 The Chemical Society of Japan",
year = "2020",
doi = "10.1246/cl.190876",
language = "English",
volume = "49",
pages = "222--224",
journal = "Chemistry Letters",
issn = "0366-7022",
publisher = "The Chemical Society of Japan",
number = "3",
}
