T. Numaga, M. Wakamori, Y. Mori

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

17 Citations (Scopus)


Canonical transient receptor potential 7 (TRPC7) is the seventh identified member of the mammalian TRPC channel family, comprising nonselective cation channels activated through the phospholipase C (PLC) signaling pathway. TRPC7 is directly activated by diacylglycerol (DAG), one of the PLC products, having high sequence homology with TRPC3 and TRPC6, which are also activated by DAG. TRPC7 shows unique properties of activation, such as constitutive activity and susceptibility to negative regulation by extracellular Ca2+. Although the physiological importance of TRPC7 in the native environment remains elusive, TRPC7 would play important roles in Ca2+ signaling pathway through these characteristic features.

Original languageEnglish
Title of host publicationTransient Receptor Potential (TRP) Channels
EditorsVeit Flockerzi, Bernd Nilius
Number of pages9
Publication statusPublished - 2007

Publication series

NameHandbook of Experimental Pharmacology
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325


  • Calcium
  • Constitutive activity
  • Diacylglycerol
  • Extracellular
  • TRPC7


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