Tumor detection with carbon-11-labelled amino acids

Kazuo Kubota, Kenji Yamada, Hiroshi Fukada, Satoshi Endo, Masatoshi Ito, Yoshinao Abe, Tatsuo Yamaguchi, Takehiko Fujiwara, Tachio Sato, Kengo Ito, Seiro Yoshioka, Jun Hatazawa, Taiju Matsuzawa, Ren Iwata, Tatsuo Ido

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)


A comparative study of tumor detection with ten 11C-labeled amino acids including four newly synthesized amino acids was carried out to find the most valuable 11C-labeled amino acid for the diagnosis of cancer. 11C-l-methionine showed the highest uptake by the experimental rat hepatoma AH109A (2.7% administered dose/g at 20 min, tumor to blood ratio; 11.4). The second highest uptake was of 11C-aminocyclopentane-carboxylic acid (ACPC). The newly synthesized 11C-dl-methyl-ACPC characteristically showed higher accumulation in tumor than in liver and the tumor to liver ratio reached 3.0 at 60 min after injection. It is suggested that 11C-l-methionine and 11C-dl-methyl-ACPC are useful amino acids for the diagnosis of cancer using positron emission tomography.

Original languageEnglish
Pages (from-to)136-140
Number of pages5
JournalEuropean Journal of Nuclear Medicine
Issue number3
Publication statusPublished - 1984 Mar


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