TY - JOUR
T1 - Tumor diagnosis by pet
T2 - potential of seven tracers examined in five experimental tumors including an artificial metastasis model
AU - Ishiwata, Kiichi
AU - Takahashi, Toshihiro
AU - Iwata, Ren
AU - Tomura, Michio
AU - Tada, Masao
AU - Itoh, Jun
AU - Kameyama, Motonobu
AU - Ido, Tatsuo
N1 - Funding Information:
Acknowledgements-This work was supportedb y Grant-in-Aids for Cancer ResearchN o. 63010033a nd Scientific ResearchN o. 0157119f3r om the Ministry of Education, Sciencea nd Culture,J apan. The authorsa ppreciateD r K. Kubota and Dr H. Takahashii n the ResearchIn stitutef or Tuberculosisa nd Cancer, Tohoku University, for their stimulatingd iscussion;t he Cancer Cell Repositoryi n the ResearchIn stitutef or Tuberculosisa nd Cancerf or supplying AH109A, YS and FM3A tumorc ells;a nd Dr I. Kjima-Sudaa t Meet Co. (Tokyo) for supplying3 LL-bearingm ice. The authorsa rea lsog ratefufl or thec ooperationo f thes taff at the Cyclotron and RadioisotopeC enter.
PY - 1992/8
Y1 - 1992/8
N2 - The potential of seven tracers for the metabolic imaging of tumors by positron emission tomography was studied using five experimental tumor models. The tracers examined were 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG), 2-deoxy-2-[18F]fluoro-d-galactose (2-[18F]FdGal) and 2-deoxy-2-[18F]fluoro-l-fucose (2-[18F]FdFuc) for investigating energy metabolism. l-[methyl-11C]Methionine ([11C]Met) and 6-[18F]fluoro-l-fucose (6-[18F]FFuc) were used for assessing protein and glycoprotein synthesis, while [3H]thymidine ([3 H]Thd) and 2-deoxy-5′-[18F]fluorouridine ([18F]FdUrd) were used to investigate nucleic acid metabolism. The highest mean uptake by the five different tumors was found for [3H]Thd, followed in order by [18F]FDG, [11C]Met, 2-[18F]FdGal, [18F]FdUrd, 2-[18F]FdFuc and 6-[18F]FFuc. The tumor-to-tissue uptake ratios indicated that the nucleosides, [11C]Met and 6-[18F]FFuc were better tracers in the brain region. All the tracers except for the fucose analogs were suitable for the thoracic region, while [11C]Thd and [18 F]FDG were superior in the abdominal region. In comparison with the primary tumor model of Lewis lung carcinoma (3LL), [3H]Thd uptake in the artificial metastatic 3LL model showed the maximum enhancement, followed by [18F]FDG, [11C]Met and the other tracers. The [18F]FDG uptake correlated with the [3H]Thd uptake. [18F]FdUrd, 6-[18F]FFuc and 2-[18F]FdGal could be used for distinguishing different types of tumors. The combined use of these radiotracers can possibly allow the assessment of tumor metabolism, and this indicates the viability of tumors.
AB - The potential of seven tracers for the metabolic imaging of tumors by positron emission tomography was studied using five experimental tumor models. The tracers examined were 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG), 2-deoxy-2-[18F]fluoro-d-galactose (2-[18F]FdGal) and 2-deoxy-2-[18F]fluoro-l-fucose (2-[18F]FdFuc) for investigating energy metabolism. l-[methyl-11C]Methionine ([11C]Met) and 6-[18F]fluoro-l-fucose (6-[18F]FFuc) were used for assessing protein and glycoprotein synthesis, while [3H]thymidine ([3 H]Thd) and 2-deoxy-5′-[18F]fluorouridine ([18F]FdUrd) were used to investigate nucleic acid metabolism. The highest mean uptake by the five different tumors was found for [3H]Thd, followed in order by [18F]FDG, [11C]Met, 2-[18F]FdGal, [18F]FdUrd, 2-[18F]FdFuc and 6-[18F]FFuc. The tumor-to-tissue uptake ratios indicated that the nucleosides, [11C]Met and 6-[18F]FFuc were better tracers in the brain region. All the tracers except for the fucose analogs were suitable for the thoracic region, while [11C]Thd and [18 F]FDG were superior in the abdominal region. In comparison with the primary tumor model of Lewis lung carcinoma (3LL), [3H]Thd uptake in the artificial metastatic 3LL model showed the maximum enhancement, followed by [18F]FDG, [11C]Met and the other tracers. The [18F]FDG uptake correlated with the [3H]Thd uptake. [18F]FdUrd, 6-[18F]FFuc and 2-[18F]FdGal could be used for distinguishing different types of tumors. The combined use of these radiotracers can possibly allow the assessment of tumor metabolism, and this indicates the viability of tumors.
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U2 - 10.1016/0883-2897(92)90095-G
DO - 10.1016/0883-2897(92)90095-G
M3 - Article
C2 - 1387872
AN - SCOPUS:44049114382
SN - 0969-8051
VL - 19
SP - 611
EP - 618
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
IS - 6
ER -