Tumor-targeting chemotherapy by a xanthine oxidase-polymer conjugate that generates oxygen-free radicals in tumor tissue

Chemistry

• Xanthine 100%
• Poly(ethylene Glycol) 61%
• Hypoxanthine 16%
• Enzyme Activity 11%
• Conjugate 11%
• Antitumor 5%
• Antineoplastic Agent 5%
• % Inhibition 5%
• Dioxygen 5%
• Radical Anion 5%
• Inorganic Peroxide 5%
• Kd 5%
• Radical (Chemistry) 5%
• Hydrogen Peroxide 5%
• Lysine Residue 5%
• Succinimide 5%
• Time 5%
• Polymer 5%
• Weight 5%
• Solid 5%
• Setting 5%
• Cytotoxic 5%
• Reactive Oxygen Species 5%

Pharmacology, Toxicology and Pharmaceutical Science

• Xanthine Oxidase 100%
• Neoplasm 33%
• Tumor Growth 16%
• Hypoxanthine 16%
• Enzyme 11%
• Antitumor Activity 5%
• Anticarcinogen 5%
• Reactive Oxygen Metabolite 5%
• Polymer 5%
• Macrogol 5%
• Blood Vessel Injury 5%
• Superoxide 5%
• Lysine 5%
• Solid Malignant Neoplasm 5%
• Hydrogen Peroxide 5%
• Oxygen Radical 5%
• Macrogol Derivative 5%
• Chemotherapy 5%
• Succinimide 5%
• Mouse 5%

Immunology and Microbiology

• Growth 16%
• Tissues 16%
• Enzyme Activity 11%
• Antineoplastic Activity 11%
• Blood Vessel 11%
• Conjugate 11%
• Organ 11%
• Superoxide 5%
• Conjugation 5%
• Binding Affinity 5%
• Body Weight 5%
• Solid 5%
• Hydrogen Peroxide 5%
• Mouse 5%
• Species 5%
• Time 5%
• Liver 5%
• Aptitude 5%
• Kidney 5%
• Spleen 5%