Twenty-four-hour urinary cortisol levels before complete resection of non-small cell lung cancer and survival

Naoki Nakaya; Shin Fukudo; Nobuya Akizuki; Eisho Yoshikawa; Makoto Kobayakawa; Maiko Fujimori; Ken Shimizu; Kanji Nagai; Yutaka Nishiwaki; Yosuke Uchitomi

doi:10.1080/02841860510029635

Twenty-four-hour urinary cortisol levels before complete resection of non-small cell lung cancer and survival

Naoki Nakaya, Shin Fukudo, Nobuya Akizuki, Eisho Yoshikawa, Makoto Kobayakawa, Maiko Fujimori, Ken Shimizu, Kanji Nagai, Yutaka Nishiwaki, Yosuke Uchitomi

MED - Disability Science

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Cortisol has been speculated to play a role in survival from cancer. The objective of this study was to investigate the association between 24-h urinary cortisol levels and survival from non-small cell lung cancer. From June 1996 to April 1999, a total of 226 patients with resectable non-small cell lung cancer were enrolled. Urine samples were collected over a 24-h period before the curative resections. A total of 14 650 person-months (median =71 months, range =1-97 months) were accrued. Over the follow-up period, 56 deaths from all causes were identified through January 2004. Cox proportional hazards regression analyses were used to estimate the relative risk (RR) of death from all causes according to three categories of 24-h urinary cortisol levels. Multivariable RRs of death from all causes for individuals in the highest and intermediate categories, compared with the lowest category, were 1.09 (95% confidence interval =0.54-2.21) and 1.17 (0.55-2.46), respectively (p for trend =0.17). The present data do not support the hypothesis that 24-h urinary cortisol levels are associated with survival from non-small cell lung cancer.

Original language	English
Pages (from-to)	399-405
Number of pages	7
Journal	Acta Oncologica
Volume	44
Issue number	4
DOIs	https://doi.org/10.1080/02841860510029635
Publication status	Published - 2005

ASJC Scopus subject areas

Hematology
Oncology
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/02841860510029635

Cite this

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title = "Twenty-four-hour urinary cortisol levels before complete resection of non-small cell lung cancer and survival",

abstract = "Cortisol has been speculated to play a role in survival from cancer. The objective of this study was to investigate the association between 24-h urinary cortisol levels and survival from non-small cell lung cancer. From June 1996 to April 1999, a total of 226 patients with resectable non-small cell lung cancer were enrolled. Urine samples were collected over a 24-h period before the curative resections. A total of 14 650 person-months (median =71 months, range =1-97 months) were accrued. Over the follow-up period, 56 deaths from all causes were identified through January 2004. Cox proportional hazards regression analyses were used to estimate the relative risk (RR) of death from all causes according to three categories of 24-h urinary cortisol levels. Multivariable RRs of death from all causes for individuals in the highest and intermediate categories, compared with the lowest category, were 1.09 (95% confidence interval =0.54-2.21) and 1.17 (0.55-2.46), respectively (p for trend =0.17). The present data do not support the hypothesis that 24-h urinary cortisol levels are associated with survival from non-small cell lung cancer.",

author = "Naoki Nakaya and Shin Fukudo and Nobuya Akizuki and Eisho Yoshikawa and Makoto Kobayakawa and Maiko Fujimori and Ken Shimizu and Kanji Nagai and Yutaka Nishiwaki and Yosuke Uchitomi",

note = "Funding Information: This study was supported by the awardee of a Research Resident Fellowship from the Foundation for the Promotion of Cancer Research (Japan) for the 3rd Term Comprehensive Control Research for Cancer. The authors wish to thank Y. Kojima, N. Taguchi, and R. Katayama of the Psycho-Oncology Division, National Cancer Center Research Institute East, Kashiwa, Japan, for their research assistance.",

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AU - Nakaya, Naoki

AU - Fukudo, Shin

AU - Akizuki, Nobuya

AU - Yoshikawa, Eisho

AU - Kobayakawa, Makoto

AU - Fujimori, Maiko

AU - Shimizu, Ken

AU - Nagai, Kanji

AU - Nishiwaki, Yutaka

AU - Uchitomi, Yosuke

N1 - Funding Information: This study was supported by the awardee of a Research Resident Fellowship from the Foundation for the Promotion of Cancer Research (Japan) for the 3rd Term Comprehensive Control Research for Cancer. The authors wish to thank Y. Kojima, N. Taguchi, and R. Katayama of the Psycho-Oncology Division, National Cancer Center Research Institute East, Kashiwa, Japan, for their research assistance.

PY - 2005

Y1 - 2005

N2 - Cortisol has been speculated to play a role in survival from cancer. The objective of this study was to investigate the association between 24-h urinary cortisol levels and survival from non-small cell lung cancer. From June 1996 to April 1999, a total of 226 patients with resectable non-small cell lung cancer were enrolled. Urine samples were collected over a 24-h period before the curative resections. A total of 14 650 person-months (median =71 months, range =1-97 months) were accrued. Over the follow-up period, 56 deaths from all causes were identified through January 2004. Cox proportional hazards regression analyses were used to estimate the relative risk (RR) of death from all causes according to three categories of 24-h urinary cortisol levels. Multivariable RRs of death from all causes for individuals in the highest and intermediate categories, compared with the lowest category, were 1.09 (95% confidence interval =0.54-2.21) and 1.17 (0.55-2.46), respectively (p for trend =0.17). The present data do not support the hypothesis that 24-h urinary cortisol levels are associated with survival from non-small cell lung cancer.

AB - Cortisol has been speculated to play a role in survival from cancer. The objective of this study was to investigate the association between 24-h urinary cortisol levels and survival from non-small cell lung cancer. From June 1996 to April 1999, a total of 226 patients with resectable non-small cell lung cancer were enrolled. Urine samples were collected over a 24-h period before the curative resections. A total of 14 650 person-months (median =71 months, range =1-97 months) were accrued. Over the follow-up period, 56 deaths from all causes were identified through January 2004. Cox proportional hazards regression analyses were used to estimate the relative risk (RR) of death from all causes according to three categories of 24-h urinary cortisol levels. Multivariable RRs of death from all causes for individuals in the highest and intermediate categories, compared with the lowest category, were 1.09 (95% confidence interval =0.54-2.21) and 1.17 (0.55-2.46), respectively (p for trend =0.17). The present data do not support the hypothesis that 24-h urinary cortisol levels are associated with survival from non-small cell lung cancer.

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Twenty-four-hour urinary cortisol levels before complete resection of non-small cell lung cancer and survival

Abstract

ASJC Scopus subject areas

UN SDGs

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