Two Cases of Eosinophilic Gastroenteritis with Colonic Involvements and Rare Complications

Abstract: Two cases of eosinophilic gastroenteritis with colonic involvements and rare complications are described. Case 1. A 39‐year‐old male was admitted with diarrhea. He had a previous medical history of early gastric cancer two years prior to this admission. A barium enema showed a diffuse nodular granularity from the transverse colon to the rectum. A sigmoidoscopic examination demonstrated nodular granularity, spotty erythema and shallow irregular ulcers with normal intervening mucosa in the rectum and the sigmoid colon. Mucosal biopsies obtained from the rectum and the sigmoid colon revealed infiltrations of eosinophils in the lamina propria and histological reexamination of the resected stomach also revealed an infiltration of eosinophils in the subserosa. One year later the patient suffered from eosinophilic cellulitis. Case 2. A 25‐year‐old female was admitted for the investigation of suspected cholestasis. Based on the findings of a liver biopsy and an endoscopic retrograde cholangiography (ERC) a diagnosis of primary sclerosing cholangitis (PSC) was made. A barium enema showed moderate granularity, lack of haustration from the cecum to the splenic flexure with a rigid ileocecal valve which was open to reflux. A colonoscopic examination revealed mucosal granularity, diffuse erythema and friability in the same regions. Mucosal biopsies obtained from both the abnormal and the normalappearing mucosa showed infiltrations of eosinophils into the lamina propria. Blood peripheral eosinophilic was present in each case.