Two cases of orbital myositis with monoclonal gammopathy of undetermined significance

Toru Nakazawa, Katsuhiro Yamaguchi, Youichi Nakagawa, Keiko Suzuki, Hidetoshi Takahashi, Makoto Tamai

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


PURPOSE: We report two cases of idiopathic orbital myositis with monoclonal gammopathy. CASE: Case one was a 47-year-old man, who had bilateral swelling of the extraocular muscles and impairment of the left optic nerve. Case two was a 27-year-old woman, who had bilateral proptosis. An immunological test showed that both patients had monoclonal gammopathy, and they were diagnosed as having monoclonal gammopathy of undetermined significance(MGUS). RESULTS: In case one, the patient achieved remission with steroid pulse therapy followed by administration of high doses of a steroid. In case two, because of repeated recurrence, the patient was treated with steroid pulse therapy and then radiation therapy to achieve final remission. CONCLUSION: We need to pay attention in the diagnosis of orbital myositis to distinguish MGUS. Such patients have an atypical clinical course and are resistant to ordinary steroid therapy.

Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalNippon Ganka Gakkai zasshi
Issue number2
Publication statusPublished - 2004 Feb


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