Two-dimensional Raman correlation analysis of diseased esophagus in a rat

Sota Takanezawa, Shin Ichi Morita, Atsushi Maruyama, Takurou N. Murakami, Norimichi Kawashima, Hiroyuki Endo, Katsunori Iijima, Tohru Asakura, Tooru Shimosegawa, Hidetoshi Sato

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1 Citation (Scopus)


Generalized two-dimensional (2D) Raman correlation analysis effectively distinguished a benign tumor from normal tissue. Line profiling Raman spectra of a rat esophagus, including a benign tumor, were measured and the generalized 2D synchronous and asynchronous spectra were calculated. In the autocorrelation area of the amide I band of proteins in the asynchronous map, a cross-like pattern was observed. A simulation study indicated that the pattern was caused by a sharp band component in the amide I band region. We considered that the benign tumor corresponded to the sharp component.

Original languageEnglish
Article number077001
JournalApplied Physics Express
Issue number7
Publication statusPublished - 2010 Jul


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