TY - JOUR
T1 - Two new 11(15→1)abeotaxanes with a 2,20-epoxy ring from the needles of Taxus canadensis
AU - Zhang, Man Li
AU - Zhang, Jing
AU - Dong, Mei
AU - Feng, Shu Hua
AU - Huo, Chang Hong
AU - Sauriol, Françoise
AU - Shi, Qing Wen
AU - Gu, Yu Cheng
AU - Kiyota, Hiromasa
AU - Cong, Bin
N1 - Funding Information:
search Foundation for the Returned Overseas Chinese Scholars of Hebei Province and State Education Ministry of P. R. China (QWS). We also appreciate the financial support by Syn-genta Ltd. (2005-Hebei Medical University-Syn-genta-01) and a grant-in-aid from Japan Society for the Promotion of Science (No. 19580120). We are pleased to thank Prof. Nobuo Suzuki (Department of Environmental Biochemistry, Chiba University, Japan) for providing the cells for the biological evaluation.
Funding Information:
The work reported in the present paper was financially supported by the Foundation for Researching New Drugs of People’s Republic of China (No. 2003AA2Z3527) and Scientific Re-
PY - 2009
Y1 - 2009
N2 - Two 11(15→1)abeotaxanes having a tetrahydrofuran ring along the carbon atoms C-2, C-3, C-4, C-20 were identified for the first time from the needles of the Canadian yew, Taxus canadensis. The compounds could be identified as 4α,10β,13α-triacetoxy-15-benzoyloxy-2α, 20β-epoxy-11(15→1)abeotax-11-ene-5α,7β,9α-triol (1) and 4α,7β,9α,10β,15-pentaacetoxy-2α,20β-epoxy- 11(15→1)abeotax-11-ene-5α,13α-diol (2) on the basis of 1D-, 2D-NMR evidence and high-resolution FABMS analysis. Compound 1 showed weak growth inhibitory activities against T-98 and MM1-CB cells in vitro.
AB - Two 11(15→1)abeotaxanes having a tetrahydrofuran ring along the carbon atoms C-2, C-3, C-4, C-20 were identified for the first time from the needles of the Canadian yew, Taxus canadensis. The compounds could be identified as 4α,10β,13α-triacetoxy-15-benzoyloxy-2α, 20β-epoxy-11(15→1)abeotax-11-ene-5α,7β,9α-triol (1) and 4α,7β,9α,10β,15-pentaacetoxy-2α,20β-epoxy- 11(15→1)abeotax-11-ene-5α,13α-diol (2) on the basis of 1D-, 2D-NMR evidence and high-resolution FABMS analysis. Compound 1 showed weak growth inhibitory activities against T-98 and MM1-CB cells in vitro.
KW - 11(15→1)Abeotaxanes
KW - Cell growth inhibition
KW - Structure elucidation
KW - Taxus canadensis
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U2 - 10.1515/znc-2009-1-208
DO - 10.1515/znc-2009-1-208
M3 - Article
C2 - 19323265
AN - SCOPUS:62549148231
SN - 0939-5075
VL - 64
SP - 43
EP - 48
JO - Zeitschrift fur Naturforschung. Section C: Biosciences
JF - Zeitschrift fur Naturforschung. Section C: Biosciences
IS - 1-2
ER -