Two pairs of mushroom body efferent neurons are required for appetitive long-term memory retrieval in drosophila

Pierre Yves Plaçais, Séverine Trannoy, Anja B. Friedrich, Hiromu Tanimoto, Thomas Preat

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

One of the challenges facing memory research is to combine network- and cellular-level descriptions of memory encoding. In this context, Drosophila offers the opportunity to decipher, down to single-cell resolution, memory-relevant circuits in connection with the mushroom bodies (MBs), prominent structures for olfactory learning and memory. Although the MB-afferent circuits involved in appetitive learning were recently described, the circuits underlying appetitive memory retrieval remain unknown. We identified two pairs of cholinergic neurons efferent from the MB α vertical lobes, named MB-V3, that are necessary for the retrieval of appetitive long-term memory (LTM). Furthermore, LTM retrieval was correlated to an enhanced response to the rewarded odor in these neurons. Strikingly, though, silencing the MB-V3 neurons did not affect short-term memory (STM) retrieval. This finding supports a scheme of parallel appetitive STM and LTM processing

Original languageEnglish
Pages (from-to)769-780
Number of pages12
JournalCell Reports
Volume5
Issue number3
DOIs
Publication statusPublished - 2013

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