TY - JOUR
T1 - Ultrasonic tissue characterization of atherosclerosis by a speed-of-sound microscanning system
AU - Saijo, Yoshifumi
AU - Filho, Esmeraldo Santos
AU - Sasaki, Hidehiko
AU - Yambe, Tomoyuki
AU - Tanaka, Motonao
AU - Hozumi, Naohiro
AU - Kobayashi, Kazuto
AU - Okada, Nagaya
N1 - Funding Information:
Manuscript received April 30, 2006; accepted October 18, 2006. This study was supported by Grants-in-Aid for Scientific Research (Scientific Research (B) 15300178, Scientific Research (B) 15360217) from the Japan Society for the Promotion of Science and Health and Labor Sciences Research Grants from the Ministry of Health, Labor and Welfare for the Research on Advanced Medical Technology (H17-Nano-001).
PY - 2007/8
Y1 - 2007/8
N2 - We have been developing a scanning acoustic microscope (SAM) system for medicine and biology featuring quantitative measurement of ultrasonic parameters of soft tissues. In the present study, we propose a new concept sound speed microscopy that can measure the thickness and speed of sound in the tissue using fast Fourier transform of a single pulsed wave instead of burst waves used in conventional SAM systems. Two coronary arteries were frozen and sectioned approximately 10 μm in thickness. They were mounted on glass slides without cover slips. The scanning time of a frame with 300 × 300 pixels was 90 s and twodimensional distribution of speed of sound was obtained. The speed of sound was 1680 ± 30 m/s in the thickened intima with collagen Aber, 1520 ± 8 m/s in the lipid deposition underlying the Abrous cap, and 1810 ± 25 m/s in a calcified lesion in the intima. These basic measurements will help in the understanding of echo intensity and pattern in intravascular ultrasound images.
AB - We have been developing a scanning acoustic microscope (SAM) system for medicine and biology featuring quantitative measurement of ultrasonic parameters of soft tissues. In the present study, we propose a new concept sound speed microscopy that can measure the thickness and speed of sound in the tissue using fast Fourier transform of a single pulsed wave instead of burst waves used in conventional SAM systems. Two coronary arteries were frozen and sectioned approximately 10 μm in thickness. They were mounted on glass slides without cover slips. The scanning time of a frame with 300 × 300 pixels was 90 s and twodimensional distribution of speed of sound was obtained. The speed of sound was 1680 ± 30 m/s in the thickened intima with collagen Aber, 1520 ± 8 m/s in the lipid deposition underlying the Abrous cap, and 1810 ± 25 m/s in a calcified lesion in the intima. These basic measurements will help in the understanding of echo intensity and pattern in intravascular ultrasound images.
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U2 - 10.1109/TUFFC.2007.427
DO - 10.1109/TUFFC.2007.427
M3 - Article
C2 - 17703660
AN - SCOPUS:34548080267
SN - 0885-3010
VL - 54
SP - 1571
EP - 1576
JO - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
JF - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
IS - 8
ER -