Ultrasonic tissue characterization of infarcted myocardium by scanning acoustic microscopy

Yoshifumi Saijo, Motonao Tanaka, Hiroaki Okawai, Hidehiko Sasaki, Shin Ichi Nitta, Floyd Dunn

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)


The purpose of this study was to ultrasonically characterize infarcted human myocardial tissue at the microscopic level by scanning acoustic microscopy. Infarcted myocardial specimens from ten cases with acute myocardial infarction were studied. Specimens were formalin fixed, paraffin embedded and sectioned to 10-μm thickness. A specially developed scanning acoustic microscope system, operating in the 100-to 200-MHz ultrasound frequency range, was used for the measurements. The values of the attenuation constant were 0.94 ± 0.04 dB/mm/MHz in normal myocardium, 0.71 ± 0.12 dB/mm/MHz in degenerated myocardium, 0.88 ± 0.47 dB/mm/MHz in granulation tissue and 1.75 ± 0.11 dB/mm/MHz in fibrosis. The values of sound speed were 1620.2 ± 8.2 m/s in normal myocardium, 1572.4 ± 10.6 m/s in degenerated myocardium, 1590.2 ± 32.5 m/s in granulation tissue and 1690.3 ± 9.1 m/s in fibrosis. The ultrasonic properties of the diseased myocardium at the microscopic level will provide important information for ultrasonic tissue characterization at the macroscopic level.

Original languageEnglish
Pages (from-to)77-85
Number of pages9
JournalUltrasound in Medicine and Biology
Issue number1
Publication statusPublished - 1997


  • Acoustic microscope
  • Acute myocardial infarction
  • Attenuation
  • Myocardium
  • Sound speed
  • Ultrasonic tissue characterization
  • Ultrasound

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics


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