Ultrasound-triggered smart drug release from a poly(dimethylsiloxane)- mesoporous silica composite

Hyun Jong Kim, Hirofumi Matsuda, Haoshen Zhou, Itaru Honma

Research output: Contribution to journalArticlepeer-review

225 Citations (Scopus)


An ultrasound-triggered controlled release system that is composed of mesoporous silica as the drug reservoir and poly(dimethylsiloxane) (PDMS) as the implantable body, is discussed. The fresh and drug-loaded mesoporous silica was characterized by using X-ray diffraction (XRD) and N2 adsorption. It was observed that the ultrasound enhanced the drug-release kinetics of PDMS and PDMS-mesoporous silica. It was also reported that ultrasound irradiation was capable or reversibly losing the tight packing of the self-assembled hydrocarbon chain. This can increase the permeability of water and drug through the polymer film. Ultrasound was found more effective on PDMS-mesoporous silica than the PDMS. The addition of mesoporous silica into PDMS can increase the ultrasonic susceptibility and reliability of pulsatile drug release. The devices based on such ultrasound-induced pulsatile release system, can be safely implanted and controlled for targeted, on-demand drug delivery.

Original languageEnglish
Pages (from-to)3083-3088
Number of pages6
JournalAdvanced Materials
Issue number23
Publication statusPublished - 2006 Dec 4


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