TY - JOUR
T1 - Understanding human health risks caused by antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARG) in water environments
T2 - Current knowledge and questions to be answered
AU - Amarasiri, Mohan
AU - Sano, Daisuke
AU - Suzuki, Satoru
N1 - Funding Information:
This work was supported by the Japan Society for the Promotion of Science under Grants18K13855 and 16H01782, and by “The Sanitation Value Chain: Designing Sanitation Systems as Eco-Community Value System” Project from Research Institute for Humanity and Nature (RIHN, Project No. 14200107).
Publisher Copyright:
© 2019 The Author(s). Published with license by Taylor and Francis Group, LLC.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Aquatic environments are identified as an ideal setting for acquisition and dissemination of antibiotic resistance, and human exposure to antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in aquatic environments may pose an additional health risk. Quantitative microbial risk assessment (QMRA) has been suggested as a suitable method to evaluate and quantify this health risk. However, information about the exposure to ARB and ARGs in aquatic environments is lacking for many scenarios and dose-response models regarding the ARB infections are not developed yet. This review summarizes the current knowledge regarding the ARB and ARGs in aquatic environments and highlights the challenging questions remaining to be answered to better forecast the health risks caused by ARB and ARGs in water environments. The questions include what are the missing information needed to quantify the human health risks caused by exposing to ARB and ARGs in aquatic environments? what are the suitable markers to evaluate the ARB/ARGs contamination in aquatic environments? how frequently do the ARG selection and propagation occur in aquatic environments? and are there any unknown hot spots? Studies on the above topics will contribute to better management of antibiotic resistance dissemination in water environments and its risks on human health. Abbreviations3GC 3rd generation cephalosporinsARB Antibiotic resistant bacteriaARG Antibiotic resistance geneCFU Colony forming unitDBP Disinfection by-productseDNA Extracellular DNAEPS Extracellular polymeric substancesHGT Horizontal gene transferISCR Insertion sequence common regionMAR Multiple antibiotic resistantMIC Minimum inhibitory concentrationMGE Mobile genetic elementsMSW Municipal solid wasteQMRA Quantitative microbial risk assessmentVBNC Viable but non-culturableWWTP Wastewater treatment plant.
AB - Aquatic environments are identified as an ideal setting for acquisition and dissemination of antibiotic resistance, and human exposure to antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in aquatic environments may pose an additional health risk. Quantitative microbial risk assessment (QMRA) has been suggested as a suitable method to evaluate and quantify this health risk. However, information about the exposure to ARB and ARGs in aquatic environments is lacking for many scenarios and dose-response models regarding the ARB infections are not developed yet. This review summarizes the current knowledge regarding the ARB and ARGs in aquatic environments and highlights the challenging questions remaining to be answered to better forecast the health risks caused by ARB and ARGs in water environments. The questions include what are the missing information needed to quantify the human health risks caused by exposing to ARB and ARGs in aquatic environments? what are the suitable markers to evaluate the ARB/ARGs contamination in aquatic environments? how frequently do the ARG selection and propagation occur in aquatic environments? and are there any unknown hot spots? Studies on the above topics will contribute to better management of antibiotic resistance dissemination in water environments and its risks on human health. Abbreviations3GC 3rd generation cephalosporinsARB Antibiotic resistant bacteriaARG Antibiotic resistance geneCFU Colony forming unitDBP Disinfection by-productseDNA Extracellular DNAEPS Extracellular polymeric substancesHGT Horizontal gene transferISCR Insertion sequence common regionMAR Multiple antibiotic resistantMIC Minimum inhibitory concentrationMGE Mobile genetic elementsMSW Municipal solid wasteQMRA Quantitative microbial risk assessmentVBNC Viable but non-culturableWWTP Wastewater treatment plant.
KW - antibiotic resistance genes
KW - Antibiotic resistant bacteria
KW - quantitative microbial risk assessment
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U2 - 10.1080/10643389.2019.1692611
DO - 10.1080/10643389.2019.1692611
M3 - Article
AN - SCOPUS:85075910953
SN - 1064-3389
VL - 50
SP - 2016
EP - 2059
JO - Critical Reviews in Environmental Science and Technology
JF - Critical Reviews in Environmental Science and Technology
IS - 19
ER -
