Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction

A. C. Collier; K. A. Milam; L. R.A. Rougée; A. Sugawara; Y. Yamauchi; M. A. Ward

doi:10.1016/j.placenta.2011.11.002

Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction

A. C. Collier, K. A. Milam, L. R.A. Rougée, A. Sugawara, Y. Yamauchi, M. A. Ward

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1, 1a2, 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone (1a1) and cholesterol (1a2, 1a6) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes.

Original language	English
Pages (from-to)	77-80
Number of pages	4
Journal	Placenta
Volume	33
Issue number	1
DOIs	https://doi.org/10.1016/j.placenta.2011.11.002
Publication status	Published - 2012 Jan
Externally published	Yes

Keywords

Assisted reproduction
Detoxification
Endocrinology
Placenta
Pregnancy

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynaecology
Developmental Biology

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10.1016/j.placenta.2011.11.002

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title = "Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction",

abstract = "Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1, 1a2, 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone (1a1) and cholesterol (1a2, 1a6) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes.",

keywords = "Assisted reproduction, Detoxification, Endocrinology, Placenta, Pregnancy",

author = "Collier, {A. C.} and Milam, {K. A.} and Roug{\'e}e, {L. R.A.} and A. Sugawara and Y. Yamauchi and Ward, {M. A.}",

note = "Funding Information: The study was supported by NIH P20RR024206 (project 4) grant to A.C.C and NIH NS060901 (subcontract) and NIH P20RR024206 (project 2) grants to M.A.W.",

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doi = "10.1016/j.placenta.2011.11.002",

language = "English",

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AU - Collier, A. C.

AU - Milam, K. A.

AU - Rougée, L. R.A.

AU - Sugawara, A.

AU - Yamauchi, Y.

AU - Ward, M. A.

N1 - Funding Information: The study was supported by NIH P20RR024206 (project 4) grant to A.C.C and NIH NS060901 (subcontract) and NIH P20RR024206 (project 2) grants to M.A.W.

PY - 2012/1

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N2 - Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1, 1a2, 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone (1a1) and cholesterol (1a2, 1a6) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes.

AB - Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1, 1a2, 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone (1a1) and cholesterol (1a2, 1a6) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes.

KW - Assisted reproduction

KW - Detoxification

KW - Endocrinology

KW - Placenta

KW - Pregnancy

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Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction

Abstract

Keywords

ASJC Scopus subject areas

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