Use of abasic site-containing DNA for electrochemical SNPs detection.

Kotaro Morita; Seiichi Nishizawa; Norio Teramae

doi:10.1093/nass/nrl045

Use of abasic site-containing DNA for electrochemical SNPs detection.

Kotaro Morita, Seiichi Nishizawa, Norio Teramae

SCI - Chemistry

Tohoku University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

In combination with an electrode modified with an abasic site-containing DNA duplex, flavins selectively bind to thymine with a useful electrochemical response, and flavins could be successfully utilized for detection of thymine-related mutations. The abasic site provides hydrophobic microenvironments for the hydrogen bond-forming ligands can recognize the specific target base in the DNA duplex, which is detected by the difference in the electrochemical response.

Original language	English
Pages (from-to)	91-92
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	50
DOIs	https://doi.org/10.1093/nass/nrl045
Publication status	Published - 2006

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title = "Use of abasic site-containing DNA for electrochemical SNPs detection.",

abstract = "In combination with an electrode modified with an abasic site-containing DNA duplex, flavins selectively bind to thymine with a useful electrochemical response, and flavins could be successfully utilized for detection of thymine-related mutations. The abasic site provides hydrophobic microenvironments for the hydrogen bond-forming ligands can recognize the specific target base in the DNA duplex, which is detected by the difference in the electrochemical response.",

author = "Kotaro Morita and Seiichi Nishizawa and Norio Teramae",

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AU - Teramae, Norio

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AB - In combination with an electrode modified with an abasic site-containing DNA duplex, flavins selectively bind to thymine with a useful electrochemical response, and flavins could be successfully utilized for detection of thymine-related mutations. The abasic site provides hydrophobic microenvironments for the hydrogen bond-forming ligands can recognize the specific target base in the DNA duplex, which is detected by the difference in the electrochemical response.

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Use of abasic site-containing DNA for electrochemical SNPs detection.

Abstract

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