Use of reference tissue models for quantification of histamine H 1 receptors in human brain by using positron emission tomography and [11C]doxepin

Atsuro Suzuki; Manabu Tashiro; Yuichi Kimura; Hideki Mochizuki; Kenji Ishii; Hiroshi Watabe; Kazuhiko Yanai; Kiichi Ishiwata; Keizo Ishii

doi:10.1007/BF02985569

Use of reference tissue models for quantification of histamine H ₁ receptors in human brain by using positron emission tomography and [¹¹C]doxepin

Atsuro Suzuki, Manabu Tashiro, Yuichi Kimura, Hideki Mochizuki, Kenji Ishii, Hiroshi Watabe, Kazuhiko Yanai, Kiichi Ishiwata, Keizo Ishii

Cyclotron and Radioisotope Center (CYRIC)

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The aim of the present study is to evaluate the validity of the simplified reference tissue model (SRTM) and of Logan graphical analysis with reference tissue (LGAR) for quantification of histamine H₁ receptors (H1Rs) by using positron emission tomography (PET) with [¹¹C]doxepin. These model-based analytic methods (SRTM and LGAR) are compared to Logan graphical analysis (LGA) and to the one-tissue model (1TM), using complete datasets obtained from 5 healthy volunteers. Since H1R concentration in the cerebellum can be regarded as negligibly small, the cerebellum was selected as the reference tissue in the present study. The comparison of binding potential (BP) values estimated by LGAR and 1TM showed good agreement; on the other hand, SRTM turned out to be unstable concerning parameter estimation in several regions of the brain. By including the results of noise analysis, LGAR became a reliable method for parameter estimation of [¹¹C]doxepin data in the cortical regions.

Original language	English
Pages (from-to)	425-433
Number of pages	9
Journal	Annals of Nuclear Medicine
Volume	19
Issue number	6
DOIs	https://doi.org/10.1007/BF02985569
Publication status	Published - 2005 Sept

Keywords

Model-based analysis
PET

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title = "Use of reference tissue models for quantification of histamine H 1 receptors in human brain by using positron emission tomography and [11C]doxepin",

abstract = "The aim of the present study is to evaluate the validity of the simplified reference tissue model (SRTM) and of Logan graphical analysis with reference tissue (LGAR) for quantification of histamine H1 receptors (H1Rs) by using positron emission tomography (PET) with [11C]doxepin. These model-based analytic methods (SRTM and LGAR) are compared to Logan graphical analysis (LGA) and to the one-tissue model (1TM), using complete datasets obtained from 5 healthy volunteers. Since H1R concentration in the cerebellum can be regarded as negligibly small, the cerebellum was selected as the reference tissue in the present study. The comparison of binding potential (BP) values estimated by LGAR and 1TM showed good agreement; on the other hand, SRTM turned out to be unstable concerning parameter estimation in several regions of the brain. By including the results of noise analysis, LGAR became a reliable method for parameter estimation of [11C]doxepin data in the cortical regions.",

keywords = "Model-based analysis, PET",

author = "Atsuro Suzuki and Manabu Tashiro and Yuichi Kimura and Hideki Mochizuki and Kenji Ishii and Hiroshi Watabe and Kazuhiko Yanai and Kiichi Ishiwata and Keizo Ishii",

note = "Funding Information: This work was partly supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology, and from the Ministry of Health, Labor and Welfare, Japan. The authors thank the volunteers in the PET measurement, Keiichi Oda, Ph.D. and Ms. Miyoko Ando for their help in PET measurements and Tom Sasaki, Ph.D. and Kazunori Kawamura, Ph.D. for the preparation of \[llC\]doxepin.T he authors also thank Professor Masatoshi Itoh, at Tohoku University Cyclotron and Radioisotope Center, for his valuable comments and advice.",

year = "2005",

month = sep,

doi = "10.1007/BF02985569",

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journal = "Annals of Nuclear Medicine",

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AU - Suzuki, Atsuro

AU - Tashiro, Manabu

AU - Kimura, Yuichi

AU - Mochizuki, Hideki

AU - Ishii, Kenji

AU - Watabe, Hiroshi

AU - Yanai, Kazuhiko

AU - Ishiwata, Kiichi

AU - Ishii, Keizo

N1 - Funding Information: This work was partly supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology, and from the Ministry of Health, Labor and Welfare, Japan. The authors thank the volunteers in the PET measurement, Keiichi Oda, Ph.D. and Ms. Miyoko Ando for their help in PET measurements and Tom Sasaki, Ph.D. and Kazunori Kawamura, Ph.D. for the preparation of \[llC\]doxepin.T he authors also thank Professor Masatoshi Itoh, at Tohoku University Cyclotron and Radioisotope Center, for his valuable comments and advice.

PY - 2005/9

Y1 - 2005/9

N2 - The aim of the present study is to evaluate the validity of the simplified reference tissue model (SRTM) and of Logan graphical analysis with reference tissue (LGAR) for quantification of histamine H1 receptors (H1Rs) by using positron emission tomography (PET) with [11C]doxepin. These model-based analytic methods (SRTM and LGAR) are compared to Logan graphical analysis (LGA) and to the one-tissue model (1TM), using complete datasets obtained from 5 healthy volunteers. Since H1R concentration in the cerebellum can be regarded as negligibly small, the cerebellum was selected as the reference tissue in the present study. The comparison of binding potential (BP) values estimated by LGAR and 1TM showed good agreement; on the other hand, SRTM turned out to be unstable concerning parameter estimation in several regions of the brain. By including the results of noise analysis, LGAR became a reliable method for parameter estimation of [11C]doxepin data in the cortical regions.

AB - The aim of the present study is to evaluate the validity of the simplified reference tissue model (SRTM) and of Logan graphical analysis with reference tissue (LGAR) for quantification of histamine H1 receptors (H1Rs) by using positron emission tomography (PET) with [11C]doxepin. These model-based analytic methods (SRTM and LGAR) are compared to Logan graphical analysis (LGA) and to the one-tissue model (1TM), using complete datasets obtained from 5 healthy volunteers. Since H1R concentration in the cerebellum can be regarded as negligibly small, the cerebellum was selected as the reference tissue in the present study. The comparison of binding potential (BP) values estimated by LGAR and 1TM showed good agreement; on the other hand, SRTM turned out to be unstable concerning parameter estimation in several regions of the brain. By including the results of noise analysis, LGAR became a reliable method for parameter estimation of [11C]doxepin data in the cortical regions.

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KW - PET

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Use of reference tissue models for quantification of histamine H ₁ receptors in human brain by using positron emission tomography and [¹¹C]doxepin

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