Use of the kinase inhibitor analog 1NM-PP1 reveals a role for toxoplasma gondii CDPK1 in the invasion step

Tatsuki Sugi; Kentaro Kato; Kyosuke Kobayashi; Shumpei Watanabe; Hitomi Kurokawa; Haiyan Gong; Kishor Pandey; Hitoshi Takemae; Hiroomi Akashi

doi:10.1128/EC.00351-09

Use of the kinase inhibitor analog 1NM-PP1 reveals a role for toxoplasma gondii CDPK1 in the invasion step

Tatsuki Sugi, Kentaro Kato, Kyosuke Kobayashi, Shumpei Watanabe, Hitomi Kurokawa, Haiyan Gong, Kishor Pandey, Hitoshi Takemae, Hiroomi Akashi

AGR - Agricultural Bioscience

The University of Tokyo

Research output: Contribution to journal › Comment/debate

49 Citations (Scopus)

Abstract

Toxoplasma gondii CDPK1 (TgCDPK1) was found to be the target of the toxoplasmocidal compound 1NM-PP1. When TgCDPK1 was mutated at position 128 from glycine to methionine, resistance was gained. Inhibition of gliding motility without inhibition of micronemal secretion by 1NM-PP1 suggests a function for TgCDPK1 in gliding motility.

Original language	English
Pages (from-to)	667-670
Number of pages	4
Journal	Eukaryotic Cell
Volume	9
Issue number	4
DOIs	https://doi.org/10.1128/EC.00351-09
Publication status	Published - 2010 Apr

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AU - Watanabe, Shumpei

AU - Kurokawa, Hitomi

AU - Gong, Haiyan

AU - Pandey, Kishor

AU - Takemae, Hitoshi

AU - Akashi, Hiroomi

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Use of the kinase inhibitor analog 1NM-PP1 reveals a role for toxoplasma gondii CDPK1 in the invasion step

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