Usefulness of serum troponin T levels on day three or four in predicting survival after acute myocardial infarction

Masahiko Kanna, Hiroshi Nonogi, Hitoshi Sumida, Shunichi Miyazaki, Satoshi Daikoku, Isao Morii, Satoshi Yasuda, Yasuo Sutani, Takeshi Baba, Yoichi Goto

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The appearance of serum troponin T (tn-T) on day 1 after acute myocardial infarction (AMI) strongly depends on coronary reperfusion. In contrast, the kinetics of tn-T release after day 1 after AMI are unaffected by the reperfusion status, and reflect the degradation of myofilaments in irreversibly damaged cells. However, it is not known whether serum tn-T levels after day 1 after AMI can be used to predict the long-term outcome. The purpose of this study was to elucidate the prognostic value of determining the tn-T level on day 3 or 4 after AMI. Serum tn-T levels on day 3 or 4 after AMI were measured in 121 patients (92 men and 29 women, mean age 65 years). Mean follow-up period was 526 days. There were 12 deaths (9 cardiac and 3 noncardiac) during the follow-up period. By Kaplan-Meier analysis, patients with tn-T levels higher than the median level (6.9 ng/ml) had a significantly higher mortality rate than those with submedian levels (p <0.01). By multivariate Cox proportional-hazards regression analysis, the serum tn-T level was an independent predictor of the long-term outcome after AMI (p <0.01). Futhermore, in patients with a first AMI, the serum tn-T level exhibited a significant negative linear correlation with left ventricular ejection fraction assessed 4 weeks after AMI (r = -0.48, p <0.001). Increased serum tn-T levels on day 3 or 4 after AMI are a powerful noninvasive predictor of poor long-term prognosis, reflecting residual left ventricular function after AMI.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
JournalAmerican Journal of Cardiology
Volume87
Issue number3
DOIs
Publication statusPublished - 2001 Feb 1

Fingerprint

Dive into the research topics of 'Usefulness of serum troponin T levels on day three or four in predicting survival after acute myocardial infarction'. Together they form a unique fingerprint.

Cite this