Utility of co-transplanting mesenchymal stem cells in islet transplantation

Naoaki Sakata; Masafumi Goto; Gumpei Yoshimatsu; Shinichi Egawa; Michiaki Unno

doi:10.3748/wjg.v17.i47.5150

Utility of co-transplanting mesenchymal stem cells in islet transplantation

Naoaki Sakata, Masafumi Goto, Gumpei Yoshimatsu, Shinichi Egawa, Michiaki Unno

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. The mechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function.

Original language	English
Pages (from-to)	5150-5155
Number of pages	6
Journal	World Journal of Gastroenterology
Volume	17
Issue number	47
DOIs	https://doi.org/10.3748/wjg.v17.i47.5150
Publication status	Published - 2011

Keywords

Angiogenesis
Bone marrow
Diabetes mellitus
Immunomodulatory
Islet transplantation
Mesenchymal stem cell
Regulatory T cell
Vascular endothelial growth factor

ASJC Scopus subject areas

Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3748/wjg.v17.i47.5150

Cite this

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title = "Utility of co-transplanting mesenchymal stem cells in islet transplantation",

abstract = "Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. The mechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function.",

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AU - Sakata, Naoaki

AU - Goto, Masafumi

AU - Yoshimatsu, Gumpei

AU - Egawa, Shinichi

AU - Unno, Michiaki

PY - 2011

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AB - Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. The mechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function.

KW - Angiogenesis

KW - Bone marrow

KW - Diabetes mellitus

KW - Immunomodulatory

KW - Islet transplantation

KW - Mesenchymal stem cell

KW - Regulatory T cell

KW - Vascular endothelial growth factor

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Utility of co-transplanting mesenchymal stem cells in islet transplantation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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