Utilization of myosin and actin bundles for the transport of molecular cargo

Hideyo Takatsuki; Kevin M. Rice; Shinichi Asano; B. Scott Day; Mizuki Hino; Kazuhiro Oiwa; Ryoki Ishikawa; Yuichi Hiratsuka; Taro Q.P. Uyeda; Kazuhiro Kohama; Eric R. Blough

doi:10.1002/smll.200901369

Utilization of myosin and actin bundles for the transport of molecular cargo

Hideyo Takatsuki, Kevin M. Rice, Shinichi Asano, B. Scott Day, Mizuki Hino, Kazuhiro Oiwa, Ryoki Ishikawa, Yuichi Hiratsuka, Taro Q.P. Uyeda, Kazuhiro Kohama, Eric R. Blough

IRIDeS - Disaster Medical Science Division

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

The utilization of motor proteins for the movement and assembly of synthetic components is currently a goal of nanoengineering research. Application of the myosin actin motor system for nanotechnological uses has been hampered due to the low flexural rigidity of individual F-actin filaments. Here it is demonstrated how actin bundling can be used to affect the translational behavior of myosin-propelled filaments, transport molecules across a motor-patterned surface, and that the movement of bundled actin can be regulated photonically. These data suggest that actin bundling may significantly improve the applicability of the myosin motor for future nanotechnological applications.

Original language	English
Pages (from-to)	452-457
Number of pages	6
Journal	Small
Volume	6
Issue number	3
DOIs	https://doi.org/10.1002/smll.200901369
Publication status	Published - 2010 Feb 5

Keywords

Actin bundles
Cargo transport
Fascin
Microchannels
Myosin

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10.1002/smll.200901369

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abstract = "The utilization of motor proteins for the movement and assembly of synthetic components is currently a goal of nanoengineering research. Application of the myosin actin motor system for nanotechnological uses has been hampered due to the low flexural rigidity of individual F-actin filaments. Here it is demonstrated how actin bundling can be used to affect the translational behavior of myosin-propelled filaments, transport molecules across a motor-patterned surface, and that the movement of bundled actin can be regulated photonically. These data suggest that actin bundling may significantly improve the applicability of the myosin motor for future nanotechnological applications.",

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AU - Takatsuki, Hideyo

AU - Rice, Kevin M.

AU - Asano, Shinichi

AU - Day, B. Scott

AU - Hino, Mizuki

AU - Oiwa, Kazuhiro

AU - Ishikawa, Ryoki

AU - Hiratsuka, Yuichi

AU - Uyeda, Taro Q.P.

AU - Kohama, Kazuhiro

AU - Blough, Eric R.

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AB - The utilization of motor proteins for the movement and assembly of synthetic components is currently a goal of nanoengineering research. Application of the myosin actin motor system for nanotechnological uses has been hampered due to the low flexural rigidity of individual F-actin filaments. Here it is demonstrated how actin bundling can be used to affect the translational behavior of myosin-propelled filaments, transport molecules across a motor-patterned surface, and that the movement of bundled actin can be regulated photonically. These data suggest that actin bundling may significantly improve the applicability of the myosin motor for future nanotechnological applications.

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Utilization of myosin and actin bundles for the transport of molecular cargo

Abstract

Keywords

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