TY - JOUR
T1 - Validating an empirical mathematical model for dynamic contrast-enhanced MR imaging of hand and wrist synovitis in rheumatoid arthritis
T2 - Correlation of model parameters with clinical disease activity
AU - Ochi, Junko
AU - Mori, Naoko
AU - Mori, Yu
AU - Mugikura, Shunji
AU - Hitachi, Shin
AU - Itoi, Eiji
AU - Takase, Kei
N1 - Funding Information:
This study was supported by a grant (JSPS KAKENHI 18K09052) from Japan Society for the Promotion of Science.The authors thank Tatsuo Nagasaka, RT of Tohoku University Hospital, Sendai, Japan, for his excellent technical assistance and kind support. The authors thank Yumi Fuji-moto in Tohoku University Hospital and Kazufumi Wata-nabe, Mari Yamaoka, Hiroki Ichida and Mayu Sawaguchi in Tohoku University for their kind support.
Funding Information:
This study was supported by a grant (JSPS KAKENHI 18K09052) from Japan Society for the Promotion of Science.
Publisher Copyright:
© 2019 Japanese Society for Magnetic Resonance in Medicine.
PY - 2020
Y1 - 2020
N2 - Purpose: To evaluate the feasibility of an empirical mathematical model (EMM) to fit dynamic contrast-enhanced MRI (DCE-MRI) data of hand and wrist synovitis and whether parameters of EMM are significantly correlated with clinical disease activity in patients with rheumatoid arthritis (RA). Methods: Thirty-one consecutive patients with RA prospectively underwent Institutional Review Board (IRB)-approved DCE-MRI scans with temporal resolution of 20 s using a 1.5T system. ROIs were placed where the highest signal increase was observed and the kinetic curves were analyzed using an EMM: ΔS(t) = A(1 − e−a t) e−b t, where ΔS is relative enhancement, t is time from when the signal increase was first observed, starting from baseline (ΔS = 0), A is the upper limit of signal intensity, a (s−1) is the rate of signal increase, and b (s−1) is the rate of signal decrease during washout. The initial slope of the kinetic curve (Aa), the initial area under the curve (AUC30), the time at which the kinetic curve reached its peak (Tpeak) and the signal enhancement ratio (SER) defined as the change in signal intensity between the initial and delayed time points (t = 60 and 300 s, respectively) were calculated. RA magnetic resonance imaging scores (RAMRIS) with and without contrast media were evaluated. These parameters or scores were compared with the Disease Activity Score (DAS) 28-erythrocyte sedimentation rate (ESR). Results: A showed a significant correlation with DAS28-ESR (r = 0.58; P = 0.0005). b, AUC30 and Tpeak were also significantly correlated with DAS28-ESR with a lesser degree (r = 0.49; P = 0.0051, r = 0.50; P = 0.0038 and r = −0.51; P = 0.0028, respectively), whereas a, Aa, SER and RAMRIS were not. Conclusion: EMM could fit the DCE-MRI data of hand and wrist synovitis. AUC30 obtained from the uptake phase of the kinetic curve as well as A, b and Tpeak obtained throughout the kinetic curve might be effective to predict the clinical disease activity.
AB - Purpose: To evaluate the feasibility of an empirical mathematical model (EMM) to fit dynamic contrast-enhanced MRI (DCE-MRI) data of hand and wrist synovitis and whether parameters of EMM are significantly correlated with clinical disease activity in patients with rheumatoid arthritis (RA). Methods: Thirty-one consecutive patients with RA prospectively underwent Institutional Review Board (IRB)-approved DCE-MRI scans with temporal resolution of 20 s using a 1.5T system. ROIs were placed where the highest signal increase was observed and the kinetic curves were analyzed using an EMM: ΔS(t) = A(1 − e−a t) e−b t, where ΔS is relative enhancement, t is time from when the signal increase was first observed, starting from baseline (ΔS = 0), A is the upper limit of signal intensity, a (s−1) is the rate of signal increase, and b (s−1) is the rate of signal decrease during washout. The initial slope of the kinetic curve (Aa), the initial area under the curve (AUC30), the time at which the kinetic curve reached its peak (Tpeak) and the signal enhancement ratio (SER) defined as the change in signal intensity between the initial and delayed time points (t = 60 and 300 s, respectively) were calculated. RA magnetic resonance imaging scores (RAMRIS) with and without contrast media were evaluated. These parameters or scores were compared with the Disease Activity Score (DAS) 28-erythrocyte sedimentation rate (ESR). Results: A showed a significant correlation with DAS28-ESR (r = 0.58; P = 0.0005). b, AUC30 and Tpeak were also significantly correlated with DAS28-ESR with a lesser degree (r = 0.49; P = 0.0051, r = 0.50; P = 0.0038 and r = −0.51; P = 0.0028, respectively), whereas a, Aa, SER and RAMRIS were not. Conclusion: EMM could fit the DCE-MRI data of hand and wrist synovitis. AUC30 obtained from the uptake phase of the kinetic curve as well as A, b and Tpeak obtained throughout the kinetic curve might be effective to predict the clinical disease activity.
KW - Dynamic contrast-enhanced magnetic resonance imaging
KW - Mathematical model
KW - Rheumatoid arthritis
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U2 - 10.2463/mrms.mp.2019-0026
DO - 10.2463/mrms.mp.2019-0026
M3 - Article
C2 - 31292313
AN - SCOPUS:85088949127
SN - 1347-3182
VL - 19
SP - 176
EP - 183
JO - Magnetic Resonance in Medical Sciences
JF - Magnetic Resonance in Medical Sciences
IS - 3
ER -