Validation of noninvasive quantification of rCBF compared with dynamic/integral method by using positron emission tomography and oxygen-15 labeled water

H. Watabe; M. Itoh; M. Mejia R.; T. Fujiwara; T. Jones; T. Nakamura

doi:10.1007/BF03168400

Validation of noninvasive quantification of rCBF compared with dynamic/integral method by using positron emission tomography and oxygen-15 labeled water

H. Watabe, M. Itoh, M. Mejia R., T. Fujiwara, T. Jones, T. Nakamura

Cyclotron and Radioisotope Center (CYRIC)

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

This study proposes a new solution for the quantification of rCBF pixel-by-pixel using PET and¹⁵O-H₂O. The method represents an application of weighted integration that uses PET image only, requiring no input function of arterial blood. It generates the rCBF image quickly and automatically. Simulation studies revealed that the calculation of rCBF was fairly stable as long as a relatively shorter scan frame time and longer scan time were selected. Calculated images of actual PET study by this method correlated significantly with those identified by the dynamic/integral method. Because this procedure could detect whole brain CBF change between different studies as accurately as by the dynamic/integral method, this procedure may be the most suitable for brain activation studies.

Original language	English
Pages (from-to)	191-198
Number of pages	8
Journal	Annals of Nuclear Medicine
Volume	9
Issue number	4
DOIs	https://doi.org/10.1007/BF03168400
Publication status	Published - 1995 Dec

Keywords

O-labeled water
noninvasive quantification
positron emission tomography
regional cerebral blood flow

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10.1007/BF03168400

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title = "Validation of noninvasive quantification of rCBF compared with dynamic/integral method by using positron emission tomography and oxygen-15 labeled water",

abstract = "This study proposes a new solution for the quantification of rCBF pixel-by-pixel using PET and15O-H2O. The method represents an application of weighted integration that uses PET image only, requiring no input function of arterial blood. It generates the rCBF image quickly and automatically. Simulation studies revealed that the calculation of rCBF was fairly stable as long as a relatively shorter scan frame time and longer scan time were selected. Calculated images of actual PET study by this method correlated significantly with those identified by the dynamic/integral method. Because this procedure could detect whole brain CBF change between different studies as accurately as by the dynamic/integral method, this procedure may be the most suitable for brain activation studies.",

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AU - Watabe, H.

AU - Itoh, M.

AU - Mejia R., M.

AU - Fujiwara, T.

AU - Jones, T.

AU - Nakamura, T.

PY - 1995/12

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AB - This study proposes a new solution for the quantification of rCBF pixel-by-pixel using PET and15O-H2O. The method represents an application of weighted integration that uses PET image only, requiring no input function of arterial blood. It generates the rCBF image quickly and automatically. Simulation studies revealed that the calculation of rCBF was fairly stable as long as a relatively shorter scan frame time and longer scan time were selected. Calculated images of actual PET study by this method correlated significantly with those identified by the dynamic/integral method. Because this procedure could detect whole brain CBF change between different studies as accurately as by the dynamic/integral method, this procedure may be the most suitable for brain activation studies.

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KW - positron emission tomography

KW - regional cerebral blood flow

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Validation of noninvasive quantification of rCBF compared with dynamic/integral method by using positron emission tomography and oxygen-15 labeled water

Abstract

Keywords

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